{"id":"W6940671202","doi":"10.6084/m9.figshare.c.6578089","title":"A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling","year":2023,"lang":"en","type":"other","venue":"Figshare","topic":"Mycorrhizal Fungi and Plant Interactions","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"","keywords":"Activin type 2 receptors; Activin receptor; Follistatin; ACVR2B; TGF beta signaling pathway; Mediator; Fibrosis; Signal transduction; Transforming growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707707,0.0002389877,0.0002934822,0.0002060247,0.0001623294,0.0005002583,0.0001788771,0.000338294,0.002202119],"category_scores_gemma":[0.00008261501,0.00007274236,0.0002009107,0.0001266161,0.0001990436,0.000264013,0.0001920703,0.0008429089,0.0004616116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002274759,"about_ca_system_score_gemma":0.0002671013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001811004,"about_ca_topic_score_gemma":0.0003788626,"domain_scores_codex":[0.9999354,0.00001318104,0.000005433897,0.00001193788,0.00001814918,0.0000158301],"domain_scores_gemma":[0.9999437,0.0000084929,0.00001725165,0.000004413712,0.000009226184,0.00001684559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005092912,0.0002153933,0.0005716332,0.0006906088,0.00003284827,0.0002179624,0.00003118657,0.0001507572,0.9606245,0.001545255,0.00132114,0.03408944],"study_design_scores_gemma":[0.0007215358,0.004405017,0.01555008,0.0002988168,0.0003467531,0.003993211,0.0001508219,0.002242969,0.8325406,0.002825214,0.136895,0.00002991448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7815971,0.1586762,0.02500474,0.009720525,0.001232109,0.000284327,0.0007758078,0.0008061915,0.02190287],"genre_scores_gemma":[0.9498313,0.03326709,0.008080663,0.001130062,0.0003842123,0.0001124363,0.0003307016,0.00004118705,0.006822509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002202119,"threshold_uncertainty_score":0.007366836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0474511891616776,"score_gpt":0.2500693221387915,"score_spread":0.2026181329771139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}