{"id":"W6941083780","doi":"10.1021/bc200672s.s001","title":"Site-Specific Fluorescent\\nLabeling and Oriented Immobilization\\nof a Triple Mutant of CYP3A4 via C64","year":2016,"lang":"en","type":"article","venue":"Figshare","topic":"Mycorrhizal Fungi and Plant Interactions","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Enzyme; Mutant; Steric effects; CYP3A4; Xenobiotic; Amino acid; In silico; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368389,0.0003455326,0.0001882706,0.0002097786,0.0001960751,0.0002130451,0.0003279802,0.0003731701,0.000805611],"category_scores_gemma":[0.00008490257,0.0002041292,0.0002959808,0.0001756431,0.0002743717,0.0001318888,0.0002624041,0.0004365199,0.0004158516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072413,"about_ca_system_score_gemma":0.000198301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128198,"about_ca_topic_score_gemma":0.001405022,"domain_scores_codex":[0.9998469,0.00001644909,0.00001246616,0.0000421663,0.00004752323,0.00003434713],"domain_scores_gemma":[0.9999315,0.00000533128,0.000024298,0.00001577239,0.000009586664,0.00001353739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001909353,0.000005900004,0.00003434958,0.000006815238,0.000001794413,0.0000243144,0.00000487267,0.00004153862,0.9994741,0.00006617387,0.00001958644,0.0003014361],"study_design_scores_gemma":[0.000002642111,0.00002907369,0.0002236797,5.314373e-7,0.000002345053,0.00005960348,0.000003068998,0.0002665725,0.9987658,0.000008413244,0.0006357041,0.000002545929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874484,0.0002471255,0.009626823,0.0001159863,0.00003242345,0.00004016489,0.0002782102,0.0001406998,0.002070216],"genre_scores_gemma":[0.9848549,0.0003592023,0.009398337,0.00004123893,0.000005869778,0.00005006871,0.0005639463,0.00005008046,0.004676255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128198,"threshold_uncertainty_score":0.002954721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813729555749015,"score_gpt":0.2030815306787453,"score_spread":0.1849442351212552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}