{"id":"W6944258956","doi":"10.17863/cam.38935","title":"Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.","year":2019,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Clinical Center; National Center for Research Resources; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; University of Cincinnati; Queensland Brain Institute; National Health and Medical Research Council; Deutsche Forschungsgemeinschaft; Leonard M. Miller School of Medicine; Göteborgs Universitet; Directorate for Biological Sciences; National Institutes of Health; College of Medicine, University of Cincinnati; Dementia Centre for Research Collaboration; National Institute on Aging; Universität Greifswald; NIHR Oxford Biomedical Research Centre; National Stroke Foundation; Vincent Fairfax Family Foundation; National Center for Global Health and Medicine; Menzies Institute for Medical Research; Hjartavernd; Medizinische Universität Graz; Peking Union Medical College; Sahlgrenska Akademin; Karl-Franzens-Universität Graz; Université de Bordeaux; BHF Centre of Research Excellence, Oxford; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute for Health and Care Research; Centers for Disease Control and Prevention; Neuroscience Research Australia; Leids Universitair Medisch Centrum; McKnight Foundation; Centre National de la Recherche Scientifique; Fonds Wetenschappelijk Onderzoek; Dr. John T. MacDonald Foundation; Universiteit Utrecht; Leonard M. Miller School of Medicine, University of Miami; Monash University; National Medical Research Council; University of Glasgow; National Heart, Lung, and Blood Institute; Universiteit Leiden; Ministero della Salute; Corona-Stiftung; Institut National de la Santé et de la Recherche Médicale; Murdoch University; Centre for Cognitive Ageing and Cognitive Epidemiology; KU Leuven; University of Pittsburgh; University of New South Wales; Singapore Eye Research Institute; Hunter Medical Research Institute; Fondation Leducq; University of Miami; University of Edinburgh; UK-India Education and Research Initiative; Massachusetts General Hospital; University College London; Scottish Funding Council; Skånes universitetssjukhus; National University of Singapore; Commonwealth Scientific and Industrial Research Organisation; Institute of Genetics; Broad Institute; Vlaamse regering; Western Sydney University; Biotechnology and Biological Sciences Research Council; Duke-NUS Medical School; University of Oxford; Shimane University; Kaiser Permanente Washington Health Research Institute; American Heart Association; National Human Genome Research Institute; University of Texas Health Science Center at Houston; Lunds Universitet; University of Sydney; Netherlands Heart Institute; Johns Hopkins University; Wellcome Trust; University of Washington; Royal Holloway, University of London; University of Tasmania; Peking Union Medical College Hospital; U.S. Department of Veterans Affairs; University of Pennsylvania; Bristol-Myers Squibb; Medical Research Council; Siemens Healthineers; Rush University; Office of Research and Development; European Commission; School of Medicine, Boston University; National University Health System; Brigham and Women's Hospital; Centre hospitalier régional universitaire de Lille; Age UK; Kaiser Permanente; Háskóli Íslands; Bundesministerium für Bildung und Forschung; British Heart Foundation","keywords":"Stroke (engine); Diabetes mellitus; Hyperintensity; Disease; Blood pressure; Ethnic group; Genetic association; Association (psychology); Vascular disease; Epidemiology; Ischemic stroke","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438033,0.0006800541,0.0006313488,0.0006563822,0.0002896448,0.0006881728,0.0004151163,0.0007062205,0.001271563],"category_scores_gemma":[0.002692234,0.0003135824,0.001865369,0.001181161,0.0002790185,0.0003406496,0.0004076466,0.0006996925,0.0001332331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809523,"about_ca_system_score_gemma":0.0002872301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003789988,"about_ca_topic_score_gemma":0.004946545,"domain_scores_codex":[0.9992987,0.0002205556,0.00006488225,0.0002802696,0.00007349879,0.00006208828],"domain_scores_gemma":[0.9990397,0.0002664654,0.0003523138,0.0001595258,0.00007375728,0.0001082507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007579854,0.00004674837,0.9879394,0.00009042129,0.0068455,0.0001891578,0.00003826313,0.0001270594,0.001026974,0.00005183443,0.0002056212,0.002681094],"study_design_scores_gemma":[0.00005840132,0.0001432428,0.9959501,0.00002443675,0.002636808,0.0003171564,0.00004711943,0.0002869946,0.0001441956,0.00009443161,0.0002914035,0.000005645525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880244,0.008507722,0.001343587,0.0002735865,0.00006715185,0.00002188695,0.001161742,0.00003326706,0.0005665984],"genre_scores_gemma":[0.9984611,0.0006083742,0.0003102265,0.00007180488,0.00003192222,0.00001249046,0.0003752694,0.000004531833,0.0001243112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003789988,"threshold_uncertainty_score":0.007605135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005159862004989178,"score_gpt":0.2059842638326283,"score_spread":0.2008244018276391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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