{"id":"W6944306977","doi":"10.17863/cam.108015","title":"Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.","year":2024,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Restless Legs Syndrome Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; Leibniz-Gemeinschaft; Natural Sciences and Engineering Research Council of Canada; Danmarks Frie Forskningsfond; Canadian Institutes of Health Research; National Institutes of Health; European Regional Development Fund; University of Thessaly; Novo Nordisk Fonden; National Institute of Neurological Disorders and Stroke; Helmholtz Zentrum München; Novo Nordisk; Univerzita Karlova v Praze; Deutsche Forschungsgemeinschaft; Emory University; Heart and Stroke Foundation of Canada; Restless Legs Syndrome Foundation","keywords":"Mendelian randomization; Restless legs syndrome; Disease; Mendelian inheritance; Locus (genetics); Genome-wide association study; Chromosome; Genetic association; Risk factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008272955,0.001914895,0.002910267,0.00227912,0.0005485472,0.002649588,0.001105964,0.001362203,0.003930721],"category_scores_gemma":[0.01700189,0.0006224001,0.01019356,0.002999937,0.0003546241,0.0008876853,0.001542215,0.00227371,0.0005023228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004921415,"about_ca_system_score_gemma":0.0008165821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005565875,"about_ca_topic_score_gemma":0.009829917,"domain_scores_codex":[0.9944312,0.003151671,0.0004598044,0.001235991,0.0004308242,0.0002905016],"domain_scores_gemma":[0.9886826,0.008084411,0.0008002361,0.001664471,0.0004461803,0.0003220899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00840568,0.00008070683,0.4073438,0.005145065,0.4873597,0.0007110357,0.0002205978,0.004408205,0.005165414,0.002053095,0.01200829,0.06709842],"study_design_scores_gemma":[0.001219837,0.0008325027,0.5153431,0.001901322,0.4329457,0.0008818707,0.0003232319,0.01001888,0.00210121,0.01512495,0.01916897,0.0001385978],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4303214,0.4780866,0.03771579,0.01236238,0.002646867,0.0001496028,0.03119151,0.001010583,0.006515228],"genre_scores_gemma":[0.9571895,0.02533682,0.006954615,0.001409838,0.0008804062,0.0001015391,0.006679551,0.0002141086,0.001233572],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008272955,"threshold_uncertainty_score":0.04375213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05470767714797121,"score_gpt":0.3047725731166252,"score_spread":0.250064895968654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}