{"id":"W6944351713","doi":"10.17863/cam.8923","title":"Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer","year":2017,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research and Materiel Command; Erasmus Universitair Medisch Centrum Rotterdam; Instituto de Salud Carlos III; Sydney Medical School; Cancer Council Western Australia; Cancer Council NSW; Cancer Council Victoria; World Cancer Research Fund; European Social Fund; Medical Research Council; Cancer Center, University of Kansas; National Institutes of Health; Centre Léon Bérard; Hellenic Health Foundation; Freistaat Sachsen; Akershus Universitetssykehus; Liga Portuguesa Contra o Cancro; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Radboud Universitair Medisch Centrum; National Health and Medical Research Council; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Universitair Medisch Centrum Groningen; Cancer Council South Australia; Istituto Oncologico Veneto; Instituto Millenium; Institut National Du Cancer; Leids Universitair Medisch Centrum; Universitetet i Bergen; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Fondation de France; Stavros Niarchos Foundation; Fisher Center for Alzheimer's Research Foundation; Peter MacCallum Cancer Centre; Kuopion Yliopistollinen Sairaala; Breast Cancer Campaign; Ministerstvo Zdravotnictví Ceské Republiky; Servicio Gallego de Salud; Institut Bergonié; Great Ormond Street Hospital for Children; Fonds Wetenschappelijk Onderzoek; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; King's College London; Gentofte Hospital; Cancerfonden; Cancer Australia; Radboud Universiteit; Russian Foundation for Basic Research; Norges Forskningsråd; Stockholms Läns Landsting; Universiteit Maastricht; Vrije Universiteit Amsterdam; University of Western Sydney; Maastricht Universitair Medisch Centrum; Ohio State University; Universiteit Leiden; University of Crete; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Robert Bosch Stiftung; Centers for Disease Control and Prevention; Jewish General Hospital; National Institute for Health and Care Research; University of Queensland; Hungarian Scientific Research Fund; Cancer Association of South Africa; Deutsches Krebsforschungszentrum; University of Aberdeen; Canadian Institutes of Health Research; Lietuvos Mokslo Taryba; European Commission; Fondation du cancer du sein du Québec; QIMR Berghofer Medical Research Institute; Universitetet i Oslo; University of Nottingham; Calvary Mater Newcastle; Nottingham University Hospitals NHS Trust; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Medisinske fakultet, Universitetet i Oslo; Hunter Medical Research Institute; Deutscher Akademischer Austauschdienst; Royal Marsden NHS Foundation Trust; Agency for Science, Technology and Research; Lon V. Smith Foundation; Vlaamse regering; Fundación Mutua Madrileña; Haukeland Universitetssjukehus; Ministère du Développement Économique, de l’Innovation et de l’Exportation; David F. and Margaret T. Grohne Family Foundation; Breast Cancer Research Foundation; Generalitat de Catalunya; Univerzita Karlova v Praze; Kansas Bioscience Authority; Xunta de Galicia; Israel Cancer Association; Dr. Ralph and Marian Falk Medical Research Trust; Agence Nationale de la Recherche; University Hospitals of Leicester NHS Trust; Ministerio de Economía y Competitividad; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Odense Universitetshospital; Central Manchester University Hospitals NHS Foundation Trust; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; Government of Canada; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Norges Teknisk-Naturvitenskapelige Universitet; Cancer Council Tasmania; Itä-Suomen Yliopisto; Genome Canada; Institut Català de la Salut; Newcastle upon Tyne Hospitals NHS Foundation Trust; Creighton University; Istituto Toscano Tumori; Trinity College Dublin; Institut Claudius Regaud; California Department of Public Health; Hospices Civils de Lyon; Sundhed og Sygdom, Det Frie Forskningsråd; Oulun Yliopisto; University of California, San Francisco; Universitetet i Tromsø; University of Southampton; Cancer Research UK; Susan G. Komen for the Cure","keywords":"Breast cancer; Estrogen receptor; Genome-wide association study; Genetic association; Mutation; Identification (biology); Disease; Cancer; Case-control study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004926872,0.0005364512,0.0004743354,0.001802455,0.0005472839,0.000677383,0.0004997234,0.0007174809,0.00298272],"category_scores_gemma":[0.001836952,0.0002194916,0.0004206745,0.001552232,0.0003679798,0.0001526386,0.0004947471,0.0003879718,0.0004092102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003355439,"about_ca_system_score_gemma":0.0002779509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003520777,"about_ca_topic_score_gemma":0.005267457,"domain_scores_codex":[0.9994654,0.00009026936,0.00008843648,0.0001313737,0.0001212136,0.0001033917],"domain_scores_gemma":[0.9987289,0.0005127093,0.0003640882,0.00006743271,0.00009578582,0.0002309556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005898836,0.0002659403,0.8735751,0.0001849446,0.000607101,0.008309145,0.0004938358,0.0005275093,0.08423205,0.0007248143,0.001089982,0.02409074],"study_design_scores_gemma":[0.0002679132,0.0004228873,0.9731141,0.00007879786,0.0004634699,0.008464895,0.0002490362,0.001215479,0.01120733,0.000462957,0.004010804,0.00004232942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973021,0.0004838548,0.0004695363,0.00008129299,0.00002010067,0.00001570292,0.0006885118,0.00001934492,0.0009195517],"genre_scores_gemma":[0.9978312,0.0001125966,0.0007572346,0.00006074326,0.00001560083,0.00001067099,0.0006208269,0.00001423375,0.0005768563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003520777,"threshold_uncertainty_score":0.009978116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006916747874049494,"score_gpt":0.2258969545103459,"score_spread":0.2189802066362964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}