{"id":"W6944432578","doi":"10.17863/cam.44383","title":"Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.","year":2019,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health; Liga Portuguesa Contra o Cancro; Ministero dello Sviluppo Economico; Jewish General Hospital; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Israel Cancer Association; National Health and Medical Research Council; Dr. Ralph and Marian Falk Medical Research Trust; Ministério da Ciência, Tecnologia e Inovação; Ministerio de Economía y Competitividad; Istituto Oncologico Veneto; Clalit Health Services; Lietuvos Mokslo Taryba; Canadian Institutes of Health Research; Cancerfonden; National Breast Cancer Foundation; Government of Canada; Cancer Research UK; University of Chicago; McGill University; Fondation du cancer du sein du Québec; Memorial Sloan-Kettering Cancer Center; NRG Oncology; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Ovarian Cancer Research Fund; Ohio State University; Ministero della Salute; Cancer Association of South Africa; Beth Israel Deaconess Medical Center; European Commission; Breast Cancer Research Foundation","keywords":"Prostate cancer; Prostate; Confidence interval; Cancer; Relative risk; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003386609,0.0002584148,0.000219954,0.0008046953,0.0002260553,0.0003445901,0.0002407507,0.0003724656,0.001777302],"category_scores_gemma":[0.001420754,0.0001355032,0.0003739104,0.0006937112,0.0002474255,0.0001211137,0.0002871707,0.0004257084,0.0001471701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001577836,"about_ca_system_score_gemma":0.0001626553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00416446,"about_ca_topic_score_gemma":0.00439596,"domain_scores_codex":[0.9997173,0.00007891883,0.00001910745,0.00007158965,0.00006821198,0.0000449371],"domain_scores_gemma":[0.9983281,0.0004071535,0.000809362,0.00007209776,0.0000887282,0.0002944568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004319531,0.00003125847,0.9926972,0.00001137924,0.000165431,0.0001882538,0.00007276231,0.00009609023,0.003935379,0.00004103812,0.00007830429,0.002250952],"study_design_scores_gemma":[0.000008344293,0.00007668528,0.9983733,0.000002959165,0.00004078924,0.0007019583,0.00004293228,0.000209141,0.0003325499,0.00004950126,0.0001585266,0.000003242206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990976,0.0003525966,0.00008283937,0.00002311231,0.000003285146,0.000002564953,0.0002092259,0.00000277239,0.0002261117],"genre_scores_gemma":[0.9992846,0.00006157222,0.0001222355,0.00001456153,0.000006888239,0.00000251355,0.0002954686,0.000002130892,0.0002101189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00416446,"threshold_uncertainty_score":0.008280456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002625179066647821,"score_gpt":0.1891588348827832,"score_spread":0.1865336558161353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}