{"id":"W6944432578","doi":"10.17863/cam.44383","title":"Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.","year":2019,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health; Liga Portuguesa Contra o Cancro; Ministero dello Sviluppo Economico; Jewish General Hospital; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Israel Cancer Association; National Health and Medical Research Council; Dr. Ralph and Marian Falk Medical Research Trust; Ministério da Ciência, Tecnologia e Inovação; Ministerio de Economía y Competitividad; Istituto Oncologico Veneto; Clalit Health Services; Lietuvos Mokslo Taryba; Canadian Institutes of Health Research; Cancerfonden; National Breast Cancer Foundation; Government of Canada; Cancer Research UK; University of Chicago; McGill University; Fondation du cancer du sein du Québec; Memorial Sloan-Kettering Cancer Center; NRG Oncology; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Ovarian Cancer Research Fund; Ohio State University; Ministero della Salute; Cancer Association of South Africa; Beth Israel Deaconess Medical Center; European Commission; Breast Cancer Research Foundation","keywords":"Prostate cancer; Prostate; Confidence interval; Cancer; Relative risk; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009533286,0.00006629065,0.0001313389,0.00005384013,0.00003241508,0.000003687699,0.00006341389,0.00007125148,0.000008607539],"category_scores_gemma":[0.000007887959,0.00007559232,0.0000201021,0.00007299311,0.00008390952,0.000008713603,0.00006562896,0.0000493146,8.918863e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007562017,"about_ca_system_score_gemma":0.0001048097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217301,"about_ca_topic_score_gemma":0.001358543,"domain_scores_codex":[0.9995333,0.00003729578,0.00006655999,0.0001873466,0.0000781237,0.0000973704],"domain_scores_gemma":[0.9995645,0.00001343505,0.0002079412,0.0001207523,0.0000678958,0.00002551884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002813375,0.00001805058,0.8615586,0.00005449148,0.0001253252,0.000001869802,0.0005741211,0.0002779243,0.133849,0.00002504061,0.0003343279,0.002899972],"study_design_scores_gemma":[0.002205672,0.000153829,0.9766524,0.000045439,0.00006132045,0.000003083594,0.0008987338,0.0001006594,0.01584774,0.00001129694,0.003895483,0.0001242938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979898,0.001237339,0.00007893655,0.000146007,0.00003084994,0.0001659476,0.0001027619,0.00000220371,0.0002461439],"genre_scores_gemma":[0.9958991,0.002128547,0.0003893996,0.00001739413,0.00001018176,6.339863e-7,0.0000153594,0.00000715375,0.001532187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1180013,"threshold_uncertainty_score":0.3082566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002625179066647821,"score_gpt":0.1891588348827832,"score_spread":0.1865336558161353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}