{"id":"W6945309711","doi":"10.25345/c5gt5fr9m","title":"MassIVE MSV000093264 - Proximity interactome mapping identifies the SUMO system as a rational drug target in ETV6-transcription factor and PAX5-TF fusion protein leukemias","year":2023,"lang":"en","type":"dataset","venue":"UC San Diego","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Drug target; Interactome; Fusion protein; Drug; Drug design; Protein–protein interaction; Fusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001612532,0.001099517,0.001107322,0.001292648,0.0005613497,0.0008745695,0.001053311,0.0006329691,0.0005004932],"category_scores_gemma":[0.0009404215,0.0008808296,0.0002906888,0.001110687,0.0003338304,0.00112132,0.0006089271,0.001941506,0.006450311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001888335,"about_ca_system_score_gemma":0.0006702942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004607324,"about_ca_topic_score_gemma":0.01707329,"domain_scores_codex":[0.9930418,0.001389108,0.001479212,0.001518517,0.001639036,0.0009323223],"domain_scores_gemma":[0.9966256,0.0005671181,0.001101914,0.001176213,0.000304561,0.0002245679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003259271,0.0001139934,0.0003077302,0.003085054,0.0002112193,0.0003296473,0.002200298,0.00003354876,0.02665189,0.00008868156,0.9666129,0.00003914269],"study_design_scores_gemma":[0.006686359,0.0003508102,0.04283585,0.02851045,0.0005860606,0.0002713855,0.02558526,0.001765455,0.01178871,0.002113262,0.8739504,0.005555952],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.224016,0.000443937,0.00001257859,0.0001763947,0.0010478,0.004570203,0.7693294,0.0003619858,0.000041636],"genre_scores_gemma":[0.1233052,0.00007291423,0.00005456123,0.00006592084,0.0005098642,0.001750283,0.8729942,0.0002320257,0.001015025],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.1036647,"threshold_uncertainty_score":0.9993643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298897890530852,"score_gpt":0.2613789738397701,"score_spread":0.2383899949344616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}