{"id":"W6947786209","doi":"10.48448/w7w5-ng39","title":"3-B-301 - Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP-signalling","year":2021,"lang":"en","type":"other","venue":"Underline Science Inc.","topic":"Species Distribution and Climate Change","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Zebrafish; Purinergic receptor; Transcriptome; Receptor; In vivo; Anticonvulsant; Pannexin; Blockade; TRPV4; Epilepsy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008563652,0.0003390264,0.000330511,0.0001676264,0.0003470592,0.0003660925,0.0005186379,0.0001910646,0.01441348],"category_scores_gemma":[0.00004940113,0.0002529738,0.00003918464,0.0008893911,0.001908613,0.0002704775,0.0004541795,0.0003338618,0.00004406428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625578,"about_ca_system_score_gemma":0.0000605463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006663863,"about_ca_topic_score_gemma":0.001639164,"domain_scores_codex":[0.9974483,0.00008741202,0.0002498509,0.0008438377,0.0007708292,0.0005997734],"domain_scores_gemma":[0.9992573,0.00005588641,0.0001913282,0.0003362476,0.000011508,0.0001477188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001250814,0.003621984,0.07070577,0.00155676,0.0002433508,0.0006389043,0.05201836,0.0002108899,0.1937462,0.008874962,0.5047895,0.1634682],"study_design_scores_gemma":[0.001245825,0.0003043284,0.01681915,0.0006061352,0.00006423621,0.0002009045,0.01785949,0.003292442,0.002571473,0.0005858035,0.9547269,0.001723287],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6025618,0.005666047,0.001070409,0.008241143,0.003570281,0.004576661,0.0003495194,0.0005523275,0.3734118],"genre_scores_gemma":[0.9225382,0.002747806,0.001005215,0.002607523,0.0004619029,0.000150058,0.0002659015,0.0002789437,0.06994444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4499375,"threshold_uncertainty_score":0.9999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772216602313361,"score_gpt":0.2585400537173705,"score_spread":0.2308178876942369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}