{"id":"W6948179110","doi":"10.48448/1caw-0w76","title":"1-B-24 - Huntingtin reduction unmasks an active form of NMDAR-dependent synapse loss","year":2021,"lang":"en","type":"other","venue":"Underline Science Inc.","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Synaptophysin; Long-term potentiation; Huntingtin; Postsynaptic potential; Synapse; Neurotransmission; Hippocampal formation; Synaptic vesicle; NMDA receptor; Excitatory postsynaptic potential","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001754436,0.0006521936,0.0008116604,0.001931587,0.0003185042,0.0002025879,0.001639304,0.0005031889,0.003774307],"category_scores_gemma":[0.0004499767,0.0006431022,0.0001552568,0.002845949,0.003007483,0.0007485563,0.0005793743,0.0007744669,0.0004701315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009102214,"about_ca_system_score_gemma":0.002169548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582293,"about_ca_topic_score_gemma":0.002557081,"domain_scores_codex":[0.9939483,0.0001648775,0.0007544588,0.001772174,0.002316881,0.001043328],"domain_scores_gemma":[0.995797,0.00005092959,0.001440515,0.001619189,0.0007151034,0.0003772484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003494232,0.003753411,0.0006694125,0.0008642761,0.0006043747,0.0002179278,0.005573132,0.0005883195,0.8605185,0.01229431,0.06253694,0.05203002],"study_design_scores_gemma":[0.005442372,0.00220083,0.001501288,0.004768667,0.0008919785,0.001328438,0.02444884,0.008938462,0.8266361,0.008526651,0.1086516,0.006664728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1833644,0.001116415,0.001853642,0.000464027,0.008207643,0.003572684,0.002073263,0.002030913,0.797317],"genre_scores_gemma":[0.6855981,0.0001411884,0.01742955,0.00008472268,0.002036297,0.00007768755,0.00102453,0.001953817,0.2916541],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.505663,"threshold_uncertainty_score":0.9997057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036537380392037,"score_gpt":0.3197323815177919,"score_spread":0.2893670077138715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}