{"id":"W6948179110","doi":"10.48448/1caw-0w76","title":"1-B-24 - Huntingtin reduction unmasks an active form of NMDAR-dependent synapse loss","year":2021,"lang":"en","type":"other","venue":"Underline Science Inc.","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Synaptophysin; Long-term potentiation; Huntingtin; Postsynaptic potential; Synapse; Neurotransmission; Hippocampal formation; Synaptic vesicle; NMDA receptor; Excitatory postsynaptic potential","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008763745,0.0002253358,0.0003256969,0.0001562873,0.0001919143,0.0002383855,0.0003450561,0.0003384888,0.003628897],"category_scores_gemma":[0.00009285709,0.0001230947,0.00019334,0.00009142981,0.0001816689,0.000119788,0.0001948377,0.0007356058,0.0009091431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003921946,"about_ca_system_score_gemma":0.0002965514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002520818,"about_ca_topic_score_gemma":0.006549554,"domain_scores_codex":[0.9998806,0.000006686373,0.00001302542,0.00002527158,0.00004123071,0.00003318372],"domain_scores_gemma":[0.9998978,0.00001069307,0.00002475588,0.00001223524,0.00001600694,0.00003843693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009187923,0.00003595744,0.00008831357,0.00002063449,0.000004940163,0.00007895454,0.00000684063,0.00000874617,0.9987543,0.00002249003,0.0001030843,0.0007839221],"study_design_scores_gemma":[0.00003999564,0.0007418041,0.01452622,0.00001450687,0.00003409973,0.0006384702,0.00003485984,0.0003358049,0.9799817,0.00003368378,0.003613017,0.000005834871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938413,0.001368119,0.0008938533,0.0002801295,0.0001003219,0.00002918696,0.000431868,0.0001436517,0.002911478],"genre_scores_gemma":[0.9881662,0.0009457222,0.001114534,0.0002057299,0.00002291173,0.00003800922,0.0005984985,0.0000524749,0.008855997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003628897,"threshold_uncertainty_score":0.01213992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036537380392037,"score_gpt":0.3197323815177919,"score_spread":0.2893670077138715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}