{"id":"W6948759741","doi":"10.48620/88985","title":"Safety and tolerability of intravenous liposomal GM1 in patients with Parkinson disease: A single-center open-label clinical phase I trial (NEON trial).","year":2025,"lang":"en","type":"article","venue":"Open Access CRIS of the University of Bern","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Cmax; Pharmacokinetics; Adverse effect; Clinical trial; Parkinson's disease; Phases of clinical research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716915,0.0001513789,0.0007759218,0.00009017659,0.0001034343,0.00004627283,0.00107219,0.00007630806,0.00007452602],"category_scores_gemma":[0.0001305726,0.0001165777,0.00009869572,0.0002409944,0.0002424703,0.0004317873,0.001574942,0.0001237249,4.712639e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001024497,"about_ca_system_score_gemma":0.0003147225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360614,"about_ca_topic_score_gemma":0.0003111742,"domain_scores_codex":[0.9984727,0.0002605472,0.000466732,0.0003857302,0.0002630404,0.0001512399],"domain_scores_gemma":[0.9986128,0.0001055234,0.0004432118,0.0005397907,0.0001566701,0.0001420527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6199351,0.02777603,0.3327157,0.000105686,0.0002602912,0.00001317492,0.00009785844,0.000001190371,0.000008378383,0.00003934996,0.00009512749,0.01895207],"study_design_scores_gemma":[0.5975199,0.003467319,0.3952628,0.0005389146,0.0006278228,2.033966e-7,0.0000768205,0.00005129769,0.000131742,0.0001019985,0.002126627,0.00009461494],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942412,0.00004691068,0.00004872795,0.0004416905,0.0001409558,0.003681787,0.0003057149,0.000004283388,0.001088684],"genre_scores_gemma":[0.9992808,0.00004785003,0.0002683634,0.00005811399,0.000009327519,0.000002258003,0.00004032514,0.000007721052,0.0002852728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06254706,"threshold_uncertainty_score":0.47539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05617731275877748,"score_gpt":0.3617420620360967,"score_spread":0.3055647492773192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}