{"id":"W6949898688","doi":"10.5281/zenodo.2617679","title":"Dysregulation of poly ADP ribose signaling in HD and its potential as a therapeutic target","year":2019,"lang":"en","type":"article","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Huntingtin; DNA damage; DNA repair; DNA; Poly ADP ribose polymerase; Oxidative phosphorylation; Programmed cell death; Mitochondrion; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016432,0.0002259554,0.0002646854,0.0001704963,0.0001165008,0.0004182148,0.0002364733,0.0004393035,0.002223952],"category_scores_gemma":[0.00007422664,0.00005838456,0.000167312,0.0001638839,0.0001667524,0.0001799388,0.0001736299,0.0006188877,0.0003913775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182367,"about_ca_system_score_gemma":0.000184095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002156906,"about_ca_topic_score_gemma":0.0004132702,"domain_scores_codex":[0.9999602,0.00001016522,0.000003340328,0.00000589637,0.000007191518,0.00001329832],"domain_scores_gemma":[0.9999655,0.000005586339,0.00001298387,0.000002991995,0.000004821341,0.000008052049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006941956,0.001840164,0.005264496,0.002186898,0.0002993153,0.002461165,0.0001580756,0.001790657,0.5887498,0.007200611,0.01233585,0.370771],"study_design_scores_gemma":[0.002836229,0.0244009,0.08891901,0.001219471,0.001122187,0.009769342,0.0005920801,0.008474424,0.4603662,0.00969104,0.3925057,0.0001033107],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5356492,0.4258359,0.006382763,0.006735465,0.0009286843,0.0002154775,0.0009975446,0.0004244461,0.02283057],"genre_scores_gemma":[0.9292764,0.06252666,0.001592378,0.0009403967,0.0003453108,0.0001167104,0.0004550862,0.00001504301,0.004731956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002223952,"threshold_uncertainty_score":0.007439792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02679784240961986,"score_gpt":0.2725597315823472,"score_spread":0.2457618891727273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}