{"id":"W6957613121","doi":"10.60692/pqhpp-8sa80","title":"PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease","year":2018,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Guelph; University of Alberta","funders":"","keywords":"Gelsolin; Cytoskeleton; Actin; Actin cytoskeleton; Heart failure; Actin remodeling; Actina","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008815611,0.0002611649,0.0001129327,0.0002604178,0.0001715012,0.0003424317,0.0001077862,0.0001927805,0.001521062],"category_scores_gemma":[0.0001293306,0.00011741,0.0001091085,0.0001510886,0.000192111,0.0001585139,0.0001804061,0.0003688904,0.0005441554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004165898,"about_ca_system_score_gemma":0.0001898564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005442486,"about_ca_topic_score_gemma":0.0005826153,"domain_scores_codex":[0.9999421,0.000006047347,0.000005053205,0.00001686564,0.00001540634,0.00001464375],"domain_scores_gemma":[0.9999175,0.000005965175,0.00003708413,0.000005983031,0.000009531278,0.00002393313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127748,0.00001075539,0.0008528045,0.00001976519,0.000003231084,0.0001034615,0.000006094843,0.00005631095,0.9972103,0.0001271881,0.00007538328,0.001421924],"study_design_scores_gemma":[0.00003296195,0.0001371742,0.1012579,0.00002190389,0.00002989091,0.001527619,0.00003804963,0.0018287,0.888938,0.0005901276,0.005587669,0.00001006956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856397,0.004360854,0.004935853,0.0004775648,0.00005029528,0.0000247201,0.0009154775,0.0002327851,0.003362624],"genre_scores_gemma":[0.9958314,0.0009801367,0.0008256967,0.00004762174,0.00001724128,0.00001211602,0.000479719,0.00001256327,0.001793592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001521062,"threshold_uncertainty_score":0.005088449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746879370475328,"score_gpt":0.243137247158703,"score_spread":0.2256684534539497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}