{"id":"W6957829327","doi":"10.60692/nhgp8-rxj80","title":"Three-Year Safety, Tolerability, and Health-Related Quality of Life Outcomes of Adjuvant Osimertinib in Patients With Resected Stage IB to IIIA EGFR-Mutated NSCLC: Updated Analysis From the Phase 3 ADAURA Trial","year":2023,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Osimertinib; Discontinuation; Placebo; Adjuvant; Adverse effect; Quality of life (healthcare)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003890465,0.0005385192,0.001089767,0.0003009473,0.0002169808,0.0006823172,0.0004133326,0.0003991244,0.0008921407],"category_scores_gemma":[0.001627437,0.000229656,0.0025726,0.0004742124,0.000270747,0.0004198556,0.0002562885,0.001219416,0.0001656209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004064225,"about_ca_system_score_gemma":0.0004080101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008112581,"about_ca_topic_score_gemma":0.002604643,"domain_scores_codex":[0.999103,0.000506661,0.00006782993,0.00008384997,0.0001625265,0.00007608721],"domain_scores_gemma":[0.9981954,0.0004636499,0.0009209728,0.0001234993,0.0001292248,0.0001673067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5038958,0.004159168,0.3262384,0.00207111,0.01836766,0.0002177059,0.0003611103,0.003534701,0.01226891,0.0001693486,0.005731119,0.122985],"study_design_scores_gemma":[0.08191289,0.06293312,0.8291651,0.0001915335,0.01488642,0.0004738073,0.0001220147,0.002143437,0.002837493,0.0002468555,0.005002758,0.00008456736],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893017,0.0072297,0.0002874685,0.0001631722,0.00003331162,0.0002158666,0.001839218,0.00001751212,0.0009120546],"genre_scores_gemma":[0.9926056,0.002166269,0.0003196691,0.0002664898,0.0001099202,0.0002615179,0.003794343,0.000007734632,0.0004684235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003890465,"threshold_uncertainty_score":0.02057499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05680745313068906,"score_gpt":0.3343058845121196,"score_spread":0.2774984313814305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}