{"id":"W6957956779","doi":"10.60692/ycz4s-saw53","title":"Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells","year":2008,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Yeast; Saccharomyces cerevisiae; Mechanism of action; DNA; DNA damage; Intracellular; Mitochondrion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446261,0.0002058863,0.0004298966,0.00009761857,0.0001590791,0.00004850404,0.0001056127,0.000152745,0.00001196862],"category_scores_gemma":[0.00001812551,0.0001694281,0.00006565797,0.00004730505,0.0001304343,0.0002572656,0.00007245255,0.00007588984,0.00001236421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002335433,"about_ca_system_score_gemma":0.0000151258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001462329,"about_ca_topic_score_gemma":4.423031e-8,"domain_scores_codex":[0.9987509,0.00002262886,0.0006396746,0.000171987,0.0002031935,0.0002116383],"domain_scores_gemma":[0.9991251,0.00002573305,0.0004166586,0.0002360874,0.00008988909,0.0001065124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002229726,0.000004425667,0.7973751,0.002301393,0.00006641613,0.000002966417,0.008900774,0.000009854156,0.1911509,0.00001212607,0.00002402782,0.0001296994],"study_design_scores_gemma":[0.0005205818,0.000009920166,0.06768616,0.0003075436,0.00003576649,0.00006473267,0.002737653,0.0002393186,0.9281651,0.000002903121,0.00002024656,0.0002100869],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99862,0.00002519735,0.00008394276,0.00001046044,0.00003053831,0.0001396749,0.0001916705,0.00008887362,0.0008095863],"genre_scores_gemma":[0.9992531,0.000001448501,0.0005784332,0.000007784638,0.00009218429,0.00001873261,0.0000215345,0.0000134565,0.00001332003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7370142,"threshold_uncertainty_score":0.6909078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04476951470215212,"score_gpt":0.2018496287713564,"score_spread":0.1570801140692043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}