{"id":"W6958116808","doi":"10.60692/f7fez-r8539","title":"Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain","year":2024,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Furin; Ebola virus; Glycoprotein; Viral envelope; Ebolavirus; Viral entry; Viral replication; Virus; VP40","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241936,0.0002403216,0.000122504,0.0001042974,0.00009973088,0.0001511857,0.0001407856,0.0001813944,0.001747115],"category_scores_gemma":[0.0001955574,0.00006221142,0.0001629111,0.00005719866,0.0001302808,0.0001097448,0.0001138714,0.0002710453,0.0003377718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565968,"about_ca_system_score_gemma":0.0001697757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302903,"about_ca_topic_score_gemma":0.0004249867,"domain_scores_codex":[0.9999322,0.00001503172,0.00000471142,0.0000140367,0.00001235321,0.00002157495],"domain_scores_gemma":[0.9999592,0.000007570583,0.0000128208,0.000006071328,0.000003905671,0.00001026537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060503,0.000114331,0.0008392308,0.00005867543,0.00001904976,0.000129246,0.00002890096,0.0001074432,0.9907994,0.0002503517,0.0003078377,0.00628509],"study_design_scores_gemma":[0.0002603767,0.00248941,0.01272952,0.00001276899,0.00005632149,0.001573458,0.0000438439,0.001591474,0.9675496,0.0002262816,0.01346021,0.000006811362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996262,0.001256459,0.001071959,0.0001247965,0.00001577488,0.00002458215,0.0001577453,0.00004251118,0.001044189],"genre_scores_gemma":[0.9946581,0.0006393075,0.001681941,0.00007766228,0.00001331834,0.00003080202,0.0005308462,0.000009151677,0.002358851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747115,"threshold_uncertainty_score":0.005844653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554484217995515,"score_gpt":0.2631329265162501,"score_spread":0.2375880843362949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}