{"id":"W6958151551","doi":"10.6084/m9.figshare.16530227","title":"Additional file 3 of Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Université de Montréal","funders":"","keywords":"Leishmania infantum; Leishmania; DNA; Topoisomerase; Drug resistance; RNA; Mutation; Acquired resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001322958,0.001078465,0.001541038,0.001819727,0.0009868213,0.002038243,0.001668067,0.001566738,0.8995092],"category_scores_gemma":[0.02281301,0.0007483898,0.001152384,0.002707899,0.000296319,0.001847791,0.001024011,0.001047429,0.2131658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001289995,"about_ca_system_score_gemma":0.001656833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006866922,"about_ca_topic_score_gemma":0.01102593,"domain_scores_codex":[0.9993394,0.00009442065,0.0001253938,0.0001788078,0.0001610123,0.0001008552],"domain_scores_gemma":[0.9835195,0.01265878,0.0008194396,0.0008679842,0.001700315,0.0004340685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006486761,0.0001002354,0.002018638,0.004753892,0.00006899308,0.0001144041,0.00005915378,0.0004107631,0.0002735885,0.0007500164,0.9806738,0.01012789],"study_design_scores_gemma":[0.009862076,0.0004122625,0.02823437,0.005517142,0.0003535066,0.0007920883,0.0003565207,0.001994948,0.001912419,0.01488674,0.9354746,0.0002032544],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0001282897,0.0000261956,0.0001913942,0.0001206091,0.00002673436,0.00005329194,0.9982898,0.0003437954,0.0008199377],"genre_scores_gemma":[0.009573482,0.0002501568,0.003635717,0.00098813,0.0001493868,0.001327891,0.9702433,0.001654327,0.01217763],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.8995092,"threshold_uncertainty_score":0.1433378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355960368452409,"score_gpt":0.2388299270548399,"score_spread":0.2252703233703158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}