{"id":"W6958294706","doi":"10.6084/m9.figshare.29432015.v1","title":"Additional file 1 of C9orf72 deficiency impairs the autophagic response to aggregated TDP-25 and exacerbates TDP-25-mediated neurodegeneration in vivo","year":2025,"lang":"en","type":"article","venue":"Figshare","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neurodegeneration; Autophagy; In vivo; C9orf72; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001559322,0.001695279,0.00202741,0.002905164,0.00140343,0.001812615,0.002682456,0.002008328,0.9153445],"category_scores_gemma":[0.01187161,0.001265828,0.001259321,0.003253223,0.0004252619,0.001857432,0.001101523,0.001535867,0.289103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001147948,"about_ca_system_score_gemma":0.001822808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005492837,"about_ca_topic_score_gemma":0.009743113,"domain_scores_codex":[0.999299,0.00008490812,0.0001105067,0.0001809346,0.0002103822,0.0001141815],"domain_scores_gemma":[0.9902748,0.00663263,0.0005998439,0.0008075833,0.0011008,0.000584317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000898427,0.0003590828,0.001209755,0.003488447,0.00009038993,0.0001970962,0.0000786444,0.0007513894,0.002445812,0.001862069,0.9768917,0.01172731],"study_design_scores_gemma":[0.01348689,0.00155422,0.03259478,0.004324772,0.0003825861,0.002285549,0.0005080716,0.006093915,0.01562488,0.02416421,0.8984254,0.0005546771],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0002393478,0.0000346915,0.0006189553,0.00009997943,0.00007216105,0.0000947493,0.9972767,0.0005338661,0.001029659],"genre_scores_gemma":[0.006614116,0.0002658181,0.007359485,0.0005762982,0.0001088162,0.002133341,0.9714972,0.00142644,0.0100185],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.9153445,"threshold_uncertainty_score":0.1207507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113078253186224,"score_gpt":0.2734167582905431,"score_spread":0.2522859757586809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}