{"id":"W6958353682","doi":"10.60692/yeh66-xpv16","title":"Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort","year":2023,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; Pacific Centre for Reproductive Medicine","funders":"","keywords":"Cohort; LRRK2; Disease; PINK1; Pathogenicity; Cohort study; Genetic testing; Genetic data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024061,0.0003517388,0.000458924,0.001548468,0.0008004882,0.0007693194,0.0004623913,0.0005359121,0.001768354],"category_scores_gemma":[0.001897247,0.0002709055,0.000378945,0.001776734,0.0003558977,0.0007740621,0.001381881,0.0005216574,0.0004396671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004726688,"about_ca_system_score_gemma":0.0006210326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02897058,"about_ca_topic_score_gemma":0.03858604,"domain_scores_codex":[0.999507,0.00008014957,0.00004098862,0.000191689,0.00007310937,0.0001070964],"domain_scores_gemma":[0.9992478,0.00008357765,0.000210032,0.0001437439,0.0001118774,0.000203056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000888576,0.00001559869,0.9969649,0.00001301034,0.0000418368,0.0002047169,0.0002308909,0.00003724888,0.0002041507,0.00005211309,0.0004963822,0.001650351],"study_design_scores_gemma":[0.000008077135,0.00004169787,0.9982635,0.00001431075,0.00003504448,0.0004468644,0.0003283916,0.00005953903,0.00003399949,0.0000494212,0.0007137673,0.000005293711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938704,0.0002803934,0.0002002069,0.0001140709,0.000006775747,0.00004052635,0.004538793,0.000008757011,0.0009400988],"genre_scores_gemma":[0.9929965,0.0002225408,0.0002902012,0.0001576527,0.00001374831,0.00007758668,0.005829002,0.000009029611,0.0004036236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02897058,"threshold_uncertainty_score":0.0576039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395360855999695,"score_gpt":0.2353899340337483,"score_spread":0.2114363254737513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}