{"id":"W6958372458","doi":"10.6084/m9.figshare.25115980.v1","title":"Additional file 1 of LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Young adult; Chemotherapy; Randomized controlled trial; Glioma; Phases of clinical research; Chemotherapy regimen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002497596,0.001106675,0.001893524,0.0008744802,0.0007862167,0.001610291,0.001355493,0.001391206,0.8179057],"category_scores_gemma":[0.02396229,0.0007649018,0.001476771,0.001853609,0.0003422789,0.00149779,0.00061822,0.001409624,0.06925395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001105841,"about_ca_system_score_gemma":0.002275232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002475691,"about_ca_topic_score_gemma":0.006442713,"domain_scores_codex":[0.9988472,0.0003905618,0.0001899777,0.0002121852,0.0001831294,0.0001769198],"domain_scores_gemma":[0.9818301,0.01337754,0.002027911,0.0008338465,0.001140931,0.000789717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.02353962,0.0007279636,0.002245386,0.01568346,0.0007136272,0.0001565708,0.00008074315,0.001392816,0.0004673102,0.00230383,0.9268433,0.0258454],"study_design_scores_gemma":[0.4112696,0.006414368,0.0284787,0.006668869,0.002287111,0.0008005978,0.000215576,0.003675859,0.00216327,0.01977782,0.5180057,0.0002425063],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001082722,0.0001865572,0.0004830686,0.0005902427,0.00008382426,0.001866261,0.9915098,0.0003735119,0.003823917],"genre_scores_gemma":[0.07016578,0.001337219,0.01302417,0.005198102,0.0008585395,0.0603944,0.7769459,0.001463528,0.07061224],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.8179057,"threshold_uncertainty_score":0.2597354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326763069493588,"score_gpt":0.2674427817218732,"score_spread":0.2541751510269374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}