{"id":"W6958549180","doi":"10.6084/m9.figshare.26630146.v1","title":"Additional file 1 of Safety and efficacy of pegunigalsidase alfa in patients with Fabry disease who were previously treated with agalsidase alfa: results from BRIDGE, a phase 3 open-label study","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Fabry disease; Selection (genetic algorithm); Enzyme replacement therapy; Clinical trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002427884,0.0009211725,0.001542874,0.0009953898,0.0005907194,0.001039108,0.0011755,0.001048006,0.800931],"category_scores_gemma":[0.02462887,0.0004883117,0.001010459,0.001796347,0.0002061571,0.001284045,0.0004902371,0.0008966696,0.07456294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001063015,"about_ca_system_score_gemma":0.001660825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002243921,"about_ca_topic_score_gemma":0.004646305,"domain_scores_codex":[0.9992341,0.000215383,0.0001890155,0.0001233404,0.0001487043,0.00008955187],"domain_scores_gemma":[0.9771049,0.01666383,0.002732627,0.0009777875,0.002036563,0.0004843429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008252878,0.0005852724,0.002535457,0.008503742,0.0003170716,0.0001219134,0.00005466045,0.0007900613,0.0002378451,0.001292677,0.9466006,0.03070789],"study_design_scores_gemma":[0.1525907,0.006101546,0.0562789,0.0115567,0.001598262,0.001521945,0.000233385,0.004437039,0.002659773,0.01637035,0.7463932,0.0002581862],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"other","genre_scores_codex":[0.0009418907,0.0001050148,0.0003896464,0.0003278889,0.00004121032,0.0008605297,0.9944243,0.0002291388,0.002680413],"genre_scores_gemma":[0.04838554,0.0008018499,0.009615576,0.002546408,0.0004437722,0.01958302,0.8887033,0.0005777822,0.02934276],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.800931,"threshold_uncertainty_score":0.2839477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734367766500784,"score_gpt":0.2640277896681375,"score_spread":0.2466841120031297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}