{"id":"W6958718022","doi":"10.6084/m9.figshare.c.7762801","title":"Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation","year":2025,"lang":"en","type":"other","venue":"Figshare","topic":"Photochemistry and Electron Transfer Studies","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University; University of British Columbia","funders":"","keywords":"Cannabis; DNA methylation; Epigenetics; Smoking cessation; Effects of cannabis; Cohort; Cannabis Dependence; Marijuana smoking","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002749073,0.0004613577,0.0004179477,0.0001014073,0.0002670283,0.00008463025,0.0003276064,0.0004799606,0.3170333],"category_scores_gemma":[0.0002869318,0.0004583452,0.0002404679,0.0002481063,0.00001863125,0.00004617789,0.00007289613,0.0005182689,0.00005300452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004087923,"about_ca_system_score_gemma":0.0002351713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001659,"about_ca_topic_score_gemma":0.0004271314,"domain_scores_codex":[0.9983612,0.00001513851,0.0002285772,0.0005633763,0.0003308609,0.0005008877],"domain_scores_gemma":[0.9991083,0.00006932543,0.0002120378,0.0003937092,0.0001292498,0.00008738715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001014349,0.00005525411,0.0008971143,0.001279159,0.001610633,0.00002561669,0.0003774535,0.000008179884,0.0001355767,0.000001377745,0.995323,0.0002764861],"study_design_scores_gemma":[0.0006452085,0.00002568923,0.0004706315,0.01886319,0.0005096897,0.00000231947,0.0002223995,0.00001141248,0.009036959,0.00001242774,0.9693012,0.0008989181],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0001755144,0.002377209,0.000003894228,0.0001867294,0.00003251822,0.0001940689,0.3134397,0.0004123085,0.6831781],"genre_scores_gemma":[0.06112739,0.00007801074,0.000005821327,0.0002483904,0.0002053246,0.0008470804,0.1945209,0.0003082396,0.7426589],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.3169803,"threshold_uncertainty_score":0.9997869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170562009966831,"score_gpt":0.2434409558006341,"score_spread":0.2217353357009658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}