{"id":"W6959205685","doi":"10.1021/acsomega.0c01282.s001","title":"Development of Nanostructured Lipid Carriers for the\\nDelivery of Idebenone in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay","year":2020,"lang":"en","type":"article","venue":"Figshare","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Idebenone; Antioxidant; Lipid peroxidation; Ataxia; Mitochondrial respiratory chain; Reactive oxygen species; Intracellular; Oxidative stress","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000791634,0.0002275123,0.0002027618,0.0001572361,0.00009067114,0.0001303328,0.0001874602,0.0003549385,0.0004561642],"category_scores_gemma":[0.00009489245,0.0001215753,0.0002246608,0.00007535628,0.00009056546,0.0001789077,0.0001551577,0.0002548739,0.0002027976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863265,"about_ca_system_score_gemma":0.0001243876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526957,"about_ca_topic_score_gemma":0.001062254,"domain_scores_codex":[0.999965,0.000003799728,0.000002648932,0.00000827363,0.00001137263,0.000008979707],"domain_scores_gemma":[0.9999675,0.000003995477,0.000009512739,0.000001713582,0.000007313849,0.00001000564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007896547,0.00002913673,0.0000438189,0.00005937785,0.000005588732,0.0001051748,0.00001450301,0.0001966156,0.9957547,0.0001309376,0.00005478653,0.003526422],"study_design_scores_gemma":[0.00006607763,0.001003073,0.001210221,0.00001612958,0.00003652855,0.0002852291,0.00002033232,0.002746029,0.9885366,0.0000595527,0.00600189,0.00001828016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808534,0.004155098,0.01067281,0.0001361498,0.000123112,0.0001486525,0.0002266563,0.0001125466,0.003571482],"genre_scores_gemma":[0.9847687,0.001935413,0.00989175,0.00008036665,0.00001223193,0.0001218867,0.0001676749,0.00001995928,0.003001961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000526957,"threshold_uncertainty_score":0.001525998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06097232400384051,"score_gpt":0.2668727458868413,"score_spread":0.2059004218830008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}