{"id":"W6962576539","doi":"10.17863/cam.97227","title":"Polygenic scores in cancer.","year":2023,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK; Government of Canada; Gray Foundation; Genome Canada","keywords":"Polygenic risk score; Limiting; Clinical trial; Risk assessment; Genetic association; MEDLINE; Relative risk; Precision medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009800914,0.0003016211,0.0003532213,0.001902272,0.0002403915,0.0006474862,0.0002623971,0.0004803528,0.007302706],"category_scores_gemma":[0.004921553,0.0001747563,0.0003239176,0.002307662,0.0003643467,0.0002621943,0.0006037102,0.0006022427,0.0007159055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280428,"about_ca_system_score_gemma":0.0003358782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007247076,"about_ca_topic_score_gemma":0.009556433,"domain_scores_codex":[0.9993887,0.0003674132,0.00002863072,0.00007337723,0.0001026094,0.0000393873],"domain_scores_gemma":[0.9980172,0.001005802,0.0002893366,0.0002114116,0.0001537145,0.000322578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007428054,0.00007024314,0.6957372,0.0003299821,0.0006770054,0.0005719172,0.0002118573,0.0009321253,0.001035359,0.01858463,0.06362671,0.2174802],"study_design_scores_gemma":[0.00004395224,0.00006600813,0.9728846,0.0001034005,0.0002109852,0.001092703,0.0000632876,0.001588933,0.0001785695,0.007015833,0.01673238,0.00001936975],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.63271,0.1854116,0.024278,0.0498246,0.002992595,0.0001032009,0.03273014,0.001247915,0.07070207],"genre_scores_gemma":[0.9708603,0.01171028,0.002605097,0.0007460967,0.001222112,0.0000443517,0.002649053,0.00005881089,0.01010388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007302706,"threshold_uncertainty_score":0.02442998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01529093152240503,"score_gpt":0.2491190480309786,"score_spread":0.2338281165085736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}