{"id":"W6962623641","doi":"10.17863/cam.72847","title":"Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.","year":2021,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Mendelian randomization; Disease; Gene expression; Gene; Single-nucleotide polymorphism; Risk factor; Genetic association","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0161468,0.0008503473,0.0009182877,0.0007961687,0.0005869474,0.0007744026,0.001462226,0.0012672,0.001813347],"category_scores_gemma":[0.01739516,0.0006590868,0.002264089,0.001286489,0.0009795144,0.0003972639,0.0006418493,0.0009354848,0.0002541314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006668094,"about_ca_system_score_gemma":0.0006575803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004857653,"about_ca_topic_score_gemma":0.002789617,"domain_scores_codex":[0.9858035,0.0100504,0.0006553118,0.002248189,0.0008351636,0.0004074628],"domain_scores_gemma":[0.9847031,0.005605526,0.004395405,0.00440309,0.0004511686,0.0004418215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03349652,0.0004608308,0.9380794,0.0001907743,0.01206497,0.0005869854,0.000344129,0.001160135,0.002323203,0.0010198,0.00129241,0.008980911],"study_design_scores_gemma":[0.005549444,0.00464793,0.9563876,0.00007539451,0.007633076,0.002212154,0.0002054296,0.01618743,0.001468354,0.002670795,0.002857748,0.0001044915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908064,0.000864185,0.006009738,0.0001372434,0.00004923607,0.0002113802,0.001543068,0.00006665027,0.000312146],"genre_scores_gemma":[0.9940047,0.0001523025,0.004136522,0.00008366502,0.0000238775,0.0002632151,0.0009917149,0.00002285048,0.0003211288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0161468,"threshold_uncertainty_score":0.08539343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05709074062165187,"score_gpt":0.2624988588548291,"score_spread":0.2054081182331772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}