{"id":"W6963907147","doi":"10.21953/lse.00004621","title":"Entry to market of new medicines and medicines treating rare diseases: issues arising from value assessment processes in the European Union, the United Kingdom and Canada","year":2023,"lang":"en","type":"dissertation","venue":"London School of Economics and Political Science Theses Online (London School of Economics and Political Science)","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Orphan drug; Access to medicines; Equity (law); Health technology; Health care; Market access; Delphi method; Authorization","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08189098,0.00046035,0.0009159999,0.00421519,0.01741464,0.04542188,0.003390565,0.005242618,0.003440662],"category_scores_gemma":[0.1207097,0.0008240937,0.001159277,0.007699796,0.02130839,0.01029252,0.008599951,0.005444506,0.000333716],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.2255105,"about_ca_system_score_gemma":0.3108447,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9249826,"about_ca_topic_score_gemma":0.9320112,"domain_scores_codex":[0.90163,0.04098568,0.005693987,0.004251057,0.03468341,0.01275589],"domain_scores_gemma":[0.8269973,0.1058413,0.006959228,0.003807957,0.04454507,0.01184901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002972208,0.0001633578,0.04506283,0.001670595,0.0001505353,0.002210158,0.1169289,0.004352659,0.0007083985,0.5496342,0.02977887,0.2490423],"study_design_scores_gemma":[0.0001176109,0.000244344,0.1143339,0.01060096,0.0002406177,0.001307644,0.2441603,0.00885304,0.002595649,0.1305905,0.4861807,0.0007748274],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3587564,0.04633895,0.01750282,0.2872536,0.0006918116,0.0009698517,0.001005886,0.000143623,0.2873369],"genre_scores_gemma":[0.9665454,0.008537928,0.01098747,0.007115486,0.00006133589,0.0001108564,0.0001780562,0.00005929551,0.006404218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7744895,"threshold_uncertainty_score":0.898298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.10688035778459,"score_gpt":0.4057651125026452,"score_spread":0.2988847547180551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}