{"id":"W6964115282","doi":"10.25345/c5np1wv52","title":"MassIVE MSV000093052 - H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells","year":2023,"lang":"en","type":"dataset","venue":"UC San Diego","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill Genome Centre","funders":"","keywords":"Mutant; Histone; Glioma; Mutation; Cell culture; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.002411477,0.002186191,0.003238687,0.004961641,0.0002137761,0.0001440787,0.002915949,0.001659928,0.001959754],"category_scores_gemma":[0.001141688,0.002279021,0.0007239122,0.004886074,0.0006261588,0.0004134671,0.001610519,0.002567366,0.04421489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002562209,"about_ca_system_score_gemma":0.001052639,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01428398,"about_ca_topic_score_gemma":0.009930216,"domain_scores_codex":[0.9859545,0.001631928,0.00336932,0.00303298,0.003488677,0.00252255],"domain_scores_gemma":[0.9918361,0.0005971575,0.002644255,0.003824003,0.0003746987,0.0007237512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000763351,0.001283293,0.000008462987,0.001435868,0.0004354579,0.03227281,0.0002793433,0.0002030667,0.07805336,0.00003308445,0.8849946,0.0002372618],"study_design_scores_gemma":[0.0135708,0.001640594,0.001439282,0.002157994,0.001689049,0.000732668,0.0007516553,0.0001641933,0.04956585,0.002037423,0.9199424,0.006308078],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.06138617,0.001399553,0.000005912346,0.00006745636,0.002125691,0.004494694,0.9299585,0.0004597484,0.0001022674],"genre_scores_gemma":[0.00722314,0.000259703,0.0006579552,0.00003558644,0.0006533419,0.0007615195,0.9873225,0.0007325251,0.002353747],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.05736398,"threshold_uncertainty_score":0.9997337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192855739765663,"score_gpt":0.2612931381887519,"score_spread":0.2393645807910952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}