{"id":"W6964491620","doi":"10.3205/15dgrh234","title":"Long-term (104-Week) Efficacy and Safety Profile of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients With Psoriatic Arthritis: Results From a Phase III, Randomized, Controlled Trial and Open-Label Extension (PALACE 1)","year":2015,"lang":"en","type":"article","venue":"German Medical Science (German Research Foundation)","topic":"Forest Ecology and Biodiversity Studies","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Apremilast; Safety profile; Psoriatic arthritis; Placebo; Randomized controlled trial; Clinical trial; Adverse effect; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003013027,0.001162406,0.001952261,0.0003237928,0.0005490232,0.0007290332,0.0007097035,0.0014905,0.006357485],"category_scores_gemma":[0.00200034,0.0006258785,0.002046848,0.0004142689,0.0008643402,0.001239632,0.0003713306,0.003331386,0.0009242971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005167483,"about_ca_system_score_gemma":0.0007619435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003682272,"about_ca_topic_score_gemma":0.0009647585,"domain_scores_codex":[0.9991653,0.000355931,0.0001026677,0.0001825672,0.00009863912,0.00009488221],"domain_scores_gemma":[0.998137,0.0004672252,0.0006877,0.0001868657,0.0001159095,0.0004052753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9071237,0.01897229,0.006334135,0.001375068,0.002062034,0.0001158161,0.0001409837,0.0005704025,0.01238548,0.00005708632,0.001011266,0.04985162],"study_design_scores_gemma":[0.6249135,0.3378938,0.03050691,0.0000723711,0.001706384,0.0002593991,0.00005009238,0.0002943093,0.003009068,0.0001194468,0.001126016,0.00004862056],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989199,0.00582558,0.0004027309,0.0002776447,0.0000924017,0.00141282,0.001485242,0.00005335686,0.001251294],"genre_scores_gemma":[0.9902996,0.001759161,0.001404997,0.0008471324,0.0002888191,0.001531009,0.002306782,0.00001634359,0.001545963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006357485,"threshold_uncertainty_score":0.02126795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06517008747215224,"score_gpt":0.3572458386726607,"score_spread":0.2920757512005084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}