{"id":"W6964847623","doi":"10.26181/26974417.v1","title":"Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer's disease","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Forest Ecology and Biodiversity Studies","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; BioClinica; Pfizer; Biogen; State Government of Victoria; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association; U.S. Department of Agriculture; Foundation for the National Institutes of Health","keywords":"Cognitive decline; Disease; Inflammation; Atrophy; Biomarker; Neuroimaging; Cognition; Dementia; Peripheral","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005723813,0.0003332886,0.0003241088,0.0009374406,0.0004197431,0.0005496397,0.0001701441,0.0002307424,0.003346662],"category_scores_gemma":[0.001278803,0.0001010823,0.000222876,0.0009932214,0.0003106016,0.0003003986,0.0004294845,0.0002930256,0.0002908949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938812,"about_ca_system_score_gemma":0.0001563433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00268112,"about_ca_topic_score_gemma":0.00460824,"domain_scores_codex":[0.9997595,0.00007430366,0.00002241987,0.00006817779,0.00004049761,0.00003506815],"domain_scores_gemma":[0.9990842,0.00008207628,0.0006041093,0.0000567719,0.00008420773,0.00008862603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005986274,0.0001087802,0.9793962,0.00009674717,0.000183586,0.0001366773,0.0001705319,0.00007706144,0.003238841,0.0001324363,0.000317014,0.01554345],"study_design_scores_gemma":[0.00000277077,0.00007010177,0.9990351,0.000009898051,0.00002824111,0.000206708,0.00005496445,0.0000875689,0.0001301452,0.0001933734,0.0001786222,0.000002426774],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962211,0.001921182,0.0002917222,0.0001011601,0.00001020807,0.000006299042,0.0003184625,0.00001352976,0.001116323],"genre_scores_gemma":[0.9987391,0.0004000175,0.0002467818,0.0000233666,0.00001957969,0.000003634889,0.0001469481,0.000001758391,0.0004189149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003346662,"threshold_uncertainty_score":0.01119566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02808512183543451,"score_gpt":0.2392975342432427,"score_spread":0.2112124124078082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}