{"id":"W6976373111","doi":"10.60692/3pk9b-cpd96","title":"Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation","year":2005,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Complex Systems and Time Series Analysis","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Substantia nigra; Conformational isomerism; Heteronuclear molecule; Protein tertiary structure; Neurodegeneration; Nuclear magnetic resonance spectroscopy; Mutant; Protein folding; Alpha-synuclein","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276974,0.0005800682,0.0001868356,0.0003222896,0.000223354,0.0001933357,0.0001663105,0.0004066366,0.001148565],"category_scores_gemma":[0.0001230136,0.0001288285,0.0002713902,0.000226446,0.000286351,0.0001474243,0.0001574969,0.0002801821,0.0007082017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527987,"about_ca_system_score_gemma":0.0001109524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004240701,"about_ca_topic_score_gemma":0.000711289,"domain_scores_codex":[0.9999001,0.00002179362,0.00001530419,0.0000268425,0.00002423444,0.00001177192],"domain_scores_gemma":[0.9998714,0.00001712873,0.00005646482,0.00001433733,0.00001483451,0.00002583878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191398,0.00003145454,0.0005694571,0.00002998346,0.00001804789,0.0007962356,0.00002270879,0.00004786726,0.9964206,0.0001214766,0.0001321185,0.001690791],"study_design_scores_gemma":[0.00009197003,0.001059726,0.05290307,0.00003650749,0.0001085795,0.02293545,0.0001227,0.001813721,0.90982,0.0004578379,0.01062018,0.00003014482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951915,0.00116351,0.001715456,0.00009994036,0.00004633554,0.00002608003,0.000391173,0.0001328415,0.001233231],"genre_scores_gemma":[0.9952519,0.0005895959,0.0016985,0.00006660237,0.00001885531,0.00002047237,0.0005442481,0.00003052855,0.001779259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148565,"threshold_uncertainty_score":0.003842294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03275804647069423,"score_gpt":0.1807871186927777,"score_spread":0.1480290722220835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}