{"id":"W6976890338","doi":"10.6084/m9.figshare.27872840.v1","title":"Additional file 1 of A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Physics and Engineering Research Articles","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kwantlen Polytechnic University; University of British Columbia","funders":"","keywords":"Familial hemiplegic migraine; Channel (broadcasting); Mutation; Migraine; Gating; Channelopathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001494001,0.001173605,0.001363309,0.001703807,0.001102843,0.001532113,0.002147667,0.001500004,0.8908587],"category_scores_gemma":[0.02164776,0.0007099011,0.000969563,0.002853943,0.0003475157,0.001724388,0.0009824792,0.001314298,0.1830005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009399851,"about_ca_system_score_gemma":0.001821248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007440656,"about_ca_topic_score_gemma":0.01018792,"domain_scores_codex":[0.9994013,0.00008608149,0.0001005249,0.0001569253,0.0001570943,0.00009797802],"domain_scores_gemma":[0.9814531,0.01473016,0.0009173819,0.0008887696,0.001541455,0.0004692202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005732116,0.0001800306,0.002188529,0.002491803,0.0000645603,0.0001903049,0.00006191149,0.0007083932,0.0003876693,0.00111828,0.9844452,0.007590099],"study_design_scores_gemma":[0.01483448,0.0008133115,0.04411551,0.004046356,0.0004830601,0.002069673,0.0004669555,0.003828287,0.003233358,0.02933496,0.8964479,0.000326087],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.000203459,0.00002089558,0.0002807857,0.00008845784,0.0000192182,0.00005506817,0.9982768,0.0002341325,0.0008212657],"genre_scores_gemma":[0.01192553,0.0001963956,0.003331155,0.0007458512,0.0001207483,0.001178241,0.9721354,0.001161477,0.009205137],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8908587,"threshold_uncertainty_score":0.1556768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02773512272560837,"score_gpt":0.2377697533033982,"score_spread":0.2100346305777898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}