{"id":"W6977087928","doi":"10.6084/m9.figshare.26802698.v1","title":"Additional file 1 of Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Retinal Imaging and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optina Diagnostics (Canada)","funders":"","keywords":"Disease; MEDLINE; Prospective cohort study; Eye disease; Glaucoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003748627,0.00005806894,0.0001464432,0.00009542814,0.00002394175,0.000004839036,0.00003553232,0.00002606254,0.06393687],"category_scores_gemma":[0.003071561,0.00003657101,0.00007421128,0.000228051,0.00004650869,0.00003506264,0.00001230442,0.00005096706,0.000001093426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006989006,"about_ca_system_score_gemma":0.0001773544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005354349,"about_ca_topic_score_gemma":0.000004358737,"domain_scores_codex":[0.9991022,0.0002270312,0.0002313006,0.0001389107,0.0002539027,0.00004659886],"domain_scores_gemma":[0.9981027,0.001294351,0.0001533102,0.0001115858,0.0003222646,0.00001580796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.004795929,0.004133558,0.09308063,0.004824269,0.004970136,0.00003707409,0.004713384,0.0004480129,0.01907841,0.000008414437,0.8317608,0.03214935],"study_design_scores_gemma":[0.0009869687,0.0004480047,0.9746184,0.001754266,0.001368361,0.000001579541,0.0002606736,0.01878743,0.001429529,0.0001205968,0.0001797788,0.0000443601],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.117962,0.0009855668,0.00001189626,0.0001194447,0.000009566187,0.001854764,0.8790067,0.000005179284,0.00004477136],"genre_scores_gemma":[0.9659945,9.903276e-7,0.0001189568,0.00001245614,0.00001453456,0.0009909592,0.03283653,0.000005754379,0.00002536774],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8815378,"threshold_uncertainty_score":0.9369188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07009510342123497,"score_gpt":0.3427333004767284,"score_spread":0.2726381970554934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}