{"id":"W6977351483","doi":"10.6084/m9.figshare.c.6950909","title":"Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains","year":2024,"lang":"en","type":"other","venue":"Figshare","topic":"Military Technology and Strategies","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Neuropathology; Pathogenesis; Substantia nigra; Disease; In vivo; Parkinson's disease; Central nervous system; Rodent model; Microglia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645965,0.000572656,0.0002562191,0.0002735656,0.0001050728,0.0003140802,0.0002440324,0.0004052092,0.0004857731],"category_scores_gemma":[0.00007985579,0.00018575,0.0002749096,0.0000795027,0.0003254721,0.0002415978,0.0001962547,0.000522144,0.0001942495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660416,"about_ca_system_score_gemma":0.0001791827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003634681,"about_ca_topic_score_gemma":0.0005081834,"domain_scores_codex":[0.9998887,0.00001190287,0.00001055772,0.00003539128,0.00003053946,0.00002294987],"domain_scores_gemma":[0.9999146,0.00001291578,0.00002558366,0.00001445714,0.00001072921,0.00002162423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002938073,0.00003149994,0.0000606366,0.00003233844,0.0000039827,0.00005794792,0.00001178766,0.00006582072,0.999012,0.00008049847,0.00001905584,0.0005950752],"study_design_scores_gemma":[0.00003025193,0.00107585,0.002162486,0.00001552124,0.0000310944,0.000555157,0.00002291358,0.001681121,0.9925323,0.0001149672,0.001771117,0.000007232171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981547,0.001458419,0.01455666,0.00007028794,0.00006024581,0.0001109367,0.0002766918,0.0002712139,0.001648602],"genre_scores_gemma":[0.9821444,0.001351502,0.01240033,0.00004719962,0.00001656984,0.0001267788,0.0003694384,0.00003998169,0.003503742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000572656,"threshold_uncertainty_score":0.001625061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060988244810318,"score_gpt":0.2205901000113091,"score_spread":0.2099802175632059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}