{"id":"W6977399560","doi":"10.6084/m9.figshare.27932603","title":"Additional file 1 of ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Myeloid leukemia; Gene isoform; Leukemia; Gene; Myeloid; Mutation; Focus (optics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001184069,0.001504801,0.001472719,0.003294333,0.001003339,0.001658087,0.00193124,0.001795462,0.8831433],"category_scores_gemma":[0.01536377,0.0007458467,0.001329443,0.003028637,0.0003969873,0.00132949,0.00098353,0.00105791,0.2360535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001057191,"about_ca_system_score_gemma":0.001466239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005040443,"about_ca_topic_score_gemma":0.01142839,"domain_scores_codex":[0.9993467,0.00007282023,0.00009387006,0.0001950386,0.0001650232,0.0001265519],"domain_scores_gemma":[0.9846489,0.01172096,0.0009460636,0.0009419974,0.001059879,0.0006821217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006397124,0.0002219802,0.005402624,0.001819509,0.00009587019,0.0003012419,0.00007480291,0.0006790877,0.0007474718,0.001017457,0.976232,0.01276824],"study_design_scores_gemma":[0.01159086,0.000624497,0.06936102,0.003291692,0.0004410849,0.002810117,0.0005242973,0.004923766,0.004520876,0.0225153,0.8790203,0.0003762422],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.000402832,0.00002253328,0.0002940939,0.00009521316,0.0000492165,0.00004746715,0.9976096,0.0004326922,0.00104627],"genre_scores_gemma":[0.009056973,0.0001272611,0.004266056,0.0006399709,0.0001131401,0.0007974193,0.9768137,0.001064004,0.007121531],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.8831433,"threshold_uncertainty_score":0.1666818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03418395578901297,"score_gpt":0.2756755609227484,"score_spread":0.2414916051337355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}