{"id":"W6977473832","doi":"10.6084/m9.figshare.28837197","title":"Additional file 1 of Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification","year":2025,"lang":"en","type":"article","venue":"Figshare","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"","keywords":"Huntingtin; Cerebrospinal fluid; Biomarker; Digital polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003621082,0.001481926,0.001413358,0.003079724,0.0008795903,0.002894076,0.002588433,0.001913779,0.8165629],"category_scores_gemma":[0.04397419,0.0008120349,0.001057234,0.003704235,0.0003873899,0.002246393,0.001995849,0.00132726,0.2972841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008906098,"about_ca_system_score_gemma":0.00176302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002669091,"about_ca_topic_score_gemma":0.004688024,"domain_scores_codex":[0.9985447,0.000362999,0.0002235274,0.0003587864,0.0003749504,0.0001350681],"domain_scores_gemma":[0.9597635,0.03210757,0.001120861,0.002559768,0.00380842,0.0006398199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003016671,0.00006194297,0.001024161,0.002375846,0.00004636298,0.00008352669,0.00004008396,0.0004369938,0.0004613979,0.0008856127,0.9806923,0.01359006],"study_design_scores_gemma":[0.001716786,0.000213593,0.01008688,0.00281208,0.0001727131,0.0007840832,0.0002573094,0.003950026,0.004180439,0.01756874,0.9580536,0.0002036463],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"other","genre_scores_codex":[0.0002498369,0.0001016702,0.002738191,0.0002427795,0.0001219223,0.00007387083,0.9920852,0.002983873,0.001402683],"genre_scores_gemma":[0.00946427,0.0004929747,0.0183005,0.001088331,0.0002881991,0.001488073,0.9541962,0.005643626,0.009037894],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.8165629,"threshold_uncertainty_score":0.2616507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05694057529206196,"score_gpt":0.2951009689420155,"score_spread":0.2381603936499536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}