{"id":"W6977639565","doi":"10.6084/m9.figshare.c.7937660.v1","title":"MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis","year":2025,"lang":"en","type":"other","venue":"Figshare","topic":"Historical, Literary, and Cultural Studies","field":"Arts and Humanities","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Université de Montréal","funders":"","keywords":"Metastasis; Melanoma; Downregulation and upregulation; Cholesterol; Crizotinib; Cancer; In vivo; Cancer cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002560233,0.0004621981,0.0007278211,0.0003961376,0.0003079582,0.0004789807,0.0003056713,0.0003689871,0.001925081],"category_scores_gemma":[0.0001936363,0.0001999732,0.000514217,0.0003140629,0.0003248364,0.0001930254,0.0002352092,0.00109265,0.0007181899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658097,"about_ca_system_score_gemma":0.0005958385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001479955,"about_ca_topic_score_gemma":0.002168106,"domain_scores_codex":[0.9997191,0.00003982284,0.00003943787,0.00004859609,0.00008365559,0.0000694089],"domain_scores_gemma":[0.9998986,0.00001196924,0.0000259679,0.00001273065,0.00001943738,0.00003135007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003870879,0.0001332964,0.0002601642,0.0001781805,0.00002210502,0.00006335419,0.00002287894,0.0001488177,0.994347,0.0001396356,0.0004365113,0.003860943],"study_design_scores_gemma":[0.0001173876,0.0008728234,0.002531191,0.00001346042,0.00006823493,0.0002558604,0.00004109295,0.002136704,0.9855168,0.00006858586,0.00836583,0.0000119975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705403,0.01135521,0.008315011,0.0005184131,0.0003455866,0.0002258866,0.001504737,0.001040182,0.006154798],"genre_scores_gemma":[0.9889626,0.002575165,0.003472184,0.0002063486,0.00004109275,0.0001645912,0.0008613989,0.00005197826,0.00366473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001925081,"threshold_uncertainty_score":0.006440043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04554571582166241,"score_gpt":0.2387126643312787,"score_spread":0.1931669485096163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}