{"id":"W69779785","doi":"10.1161/circ.118.suppl_18.s_1143-b","title":"Abstract 5090: Impact of Adding a Single Allele in the 9p21 Locus to Traditional Risk Factors on Risk Classification for Coronary Heart Disease and Implications for Lipid-Modifying Therapy in the White Population of the Atherosclerosis Risk in Communities (ARIC) Study","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Health and Risk Factors","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Foundation","funders":"","keywords":"Medicine; Hazard ratio; Internal medicine; Allele; Proportional hazards model; Population; Locus (genetics); Framingham Risk Score; Genotype; Atherosclerosis Risk in Communities; Oncology; Cardiology; Disease; Confidence interval; Genetics; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009454736,0.0001399228,0.0002681722,0.0002062284,0.0003419442,0.0000141569,0.0001113101,0.00006909733,0.000002334166],"category_scores_gemma":[0.0002863303,0.00008201094,0.0002346963,0.0003780058,0.00005796249,0.0001044736,0.00000774868,0.0002317867,1.12567e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077949,"about_ca_system_score_gemma":0.00007826169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004824718,"about_ca_topic_score_gemma":0.001166606,"domain_scores_codex":[0.9984387,0.0004815177,0.0004747676,0.0001795022,0.0002594429,0.0001660473],"domain_scores_gemma":[0.9981912,0.0009306724,0.0003056409,0.0004421185,0.00008220631,0.00004821203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003663932,0.0007159541,0.968257,0.00002656563,0.00004052128,4.894024e-8,0.01262038,0.01552426,0.0003217759,0.00001985151,0.00002209146,0.002085142],"study_design_scores_gemma":[0.001871595,0.0003534548,0.9917213,0.00006660621,0.00007819333,0.000001858586,0.003919697,0.001655255,0.000005477447,0.0002417845,0.000006915726,0.00007791581],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947242,0.0001265847,0.0003088252,0.0002570589,0.00002699376,0.004084852,0.0004579799,0.000007901037,0.000005631162],"genre_scores_gemma":[0.9990457,0.0001682175,0.00003725837,0.00004523822,0.00004701232,0.0003644104,0.0002747882,0.00001702997,3.412902e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02346423,"threshold_uncertainty_score":0.7293563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1568710128403325,"score_gpt":0.3394012197736117,"score_spread":0.1825302069332792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}