{"id":"W6978093911","doi":"10.6084/m9.figshare.c.6973305.v1","title":"DNA methylation modulated genetic variant effect on gene transcriptional regulation","year":2024,"lang":"en","type":"other","venue":"Figshare","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Expression quantitative trait loci; DNA methylation; CpG site; Gene; Single-nucleotide polymorphism; Regulation of gene expression; Chromatin; Methylation; Regulatory sequence; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004702595,0.0001926462,0.0002104747,0.0004019661,0.0001456144,0.0003279874,0.0002468518,0.0001935954,0.01454677],"category_scores_gemma":[0.001329104,0.0000808755,0.000337471,0.0004411522,0.000217322,0.0001519184,0.0003050893,0.0002807423,0.0007807632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420708,"about_ca_system_score_gemma":0.0001404807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277782,"about_ca_topic_score_gemma":0.001787234,"domain_scores_codex":[0.9997393,0.00007615601,0.00001491355,0.00009520329,0.00004348394,0.00003094541],"domain_scores_gemma":[0.9994542,0.0003165734,0.00007848785,0.00009403823,0.00003487837,0.00002173095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002019581,0.0001451379,0.1711316,0.0005168106,0.0007505328,0.001126454,0.0002238011,0.007172601,0.693006,0.01087315,0.004949505,0.1080848],"study_design_scores_gemma":[0.0002079434,0.0005794273,0.4731192,0.00008642965,0.0007685727,0.002042993,0.0001644124,0.04858734,0.4295724,0.0137042,0.03107658,0.00009045051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471949,0.001609089,0.02820573,0.0005631069,0.00011705,0.0000372014,0.01239748,0.0007758308,0.009099519],"genre_scores_gemma":[0.9916251,0.0002203857,0.004187843,0.0001572221,0.00001547824,0.00001815633,0.00132266,0.00007846546,0.002374661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01454677,"threshold_uncertainty_score":0.04866385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247755166106828,"score_gpt":0.2711858648725318,"score_spread":0.2487083132114635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}