{"id":"W6980239760","doi":"","title":"Biochemical and Functional Analyses of PANX1 Variants","year":2019,"lang":"en","type":"article","venue":"Scholarship@Western (Western University)","topic":"Cardiovascular Conditions and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Allele; Missense mutation; Mutation; Function (biology); Pannexin; Phosphorylation; Allele frequency; Cancer; Cell signaling","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688489,0.0002078849,0.0001329623,0.0001392407,0.0001018809,0.0001781456,0.0001283428,0.0002240478,0.0008556622],"category_scores_gemma":[0.0002400024,0.0000568611,0.0002561813,0.0001607581,0.0001532156,0.0001349412,0.0001513935,0.0002986829,0.0001495942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181433,"about_ca_system_score_gemma":0.00009610608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007512945,"about_ca_topic_score_gemma":0.0008939996,"domain_scores_codex":[0.9998821,0.00001971005,0.00001837692,0.00003182196,0.00003029045,0.00001767244],"domain_scores_gemma":[0.9998829,0.00002342285,0.00003453881,0.00001270103,0.00001931681,0.0000269997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000756458,0.00001301288,0.0009971076,0.00001747722,0.00001024034,0.0001640269,0.00002270939,0.00007309864,0.9978955,0.00007205936,0.00001730266,0.000641854],"study_design_scores_gemma":[0.00001987204,0.0004030257,0.035576,0.00000786638,0.00006897443,0.002961753,0.0001330389,0.001893982,0.9558133,0.0001299327,0.002980608,0.00001168323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971488,0.0003168167,0.001626368,0.00003545167,0.00001253242,0.00001282138,0.0004462658,0.0000126757,0.0003883103],"genre_scores_gemma":[0.9964813,0.0001945556,0.001641269,0.00004502626,0.00000456407,0.00001223499,0.0008446652,0.00002307759,0.0007533461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008556622,"threshold_uncertainty_score":0.002862453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1048587182211369,"score_gpt":0.3294548019780264,"score_spread":0.2245960837568894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}