{"id":"W6980506378","doi":"","title":"Characterization of regulatory mechanisms of CdGAP, a negative regulator of the small GTPases Rac1 and Cdc42","year":2008,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; McGill University","keywords":"Phosphorylation; CDC42; GTPase; RAC1; Regulator; PAK1; Downregulation and upregulation; Serine; GTPase-activating protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003598444,0.0004459093,0.0007145984,0.0001323245,0.0002425665,0.000007901337,0.0004036084,0.0007330292,0.00001483656],"category_scores_gemma":[0.0003599568,0.000370454,0.0003323968,0.0002023879,0.0002022462,0.00002395092,0.000146886,0.0002758133,7.565936e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004109567,"about_ca_system_score_gemma":0.0001020007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009972212,"about_ca_topic_score_gemma":0.0002613743,"domain_scores_codex":[0.9976546,0.000334419,0.0007434366,0.0006132937,0.0003906613,0.0002636567],"domain_scores_gemma":[0.9972475,0.00007421441,0.001498177,0.0006853688,0.0003990991,0.00009562855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003959225,0.0001683571,0.00005694348,0.0003604821,0.0002295189,0.000001772487,0.00001123263,0.000001468274,0.9892595,0.002550468,9.501612e-7,0.006963343],"study_design_scores_gemma":[0.0004203834,0.0002227145,0.02165035,0.0004284577,0.0001624116,0.0000174764,0.0001076202,0.000003072794,0.9751565,0.0009502316,0.0005320125,0.0003487334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951394,0.0001546746,0.000001726154,0.000005537868,0.0002468597,0.0005266053,0.002775165,0.0000114345,0.001138623],"genre_scores_gemma":[0.9973712,0.0006156795,0.0003308675,0.00003235599,0.00002488706,0.00003146436,0.0006573597,0.00006796588,0.0008682194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02159341,"threshold_uncertainty_score":0.9998747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039471467982028,"score_gpt":0.1969717567445533,"score_spread":0.1865770420647331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}