{"id":"W6980733324","doi":"","title":"Constitutive methylation of budding yeast CENP-A contributes to chromosomal instability","year":2023,"lang":"en","type":"other","venue":"Queen Mary Research Online (Queen Mary University of London)","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; Queen Mary University of London","keywords":"Chromosome segregation; Chromatin; Histone methylation; Epigenetics; Centromere; Methylation; Kinetochore; Chromosome instability; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007982397,0.0002856521,0.0006463745,0.0006403801,0.0001138953,0.00000849577,0.0006343449,0.0006298379,0.0005389281],"category_scores_gemma":[0.0004878032,0.0003201129,0.0002200508,0.0005388248,0.0009662316,0.0000106411,0.0009955963,0.0004524192,0.00003299288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300071,"about_ca_system_score_gemma":0.0007197551,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008244907,"about_ca_topic_score_gemma":0.005016194,"domain_scores_codex":[0.9974777,0.0006353588,0.0003184781,0.0007184058,0.0003567371,0.0004933164],"domain_scores_gemma":[0.9981972,0.0002029745,0.000228292,0.0006635935,0.0005296977,0.0001782559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00766237,0.001923635,0.1051535,0.001895015,0.003803829,0.0004303601,0.0003364096,0.0001235246,0.226559,0.005335691,0.6073347,0.03944194],"study_design_scores_gemma":[0.001619466,0.0009974218,0.01926016,0.0003979957,0.00007864422,0.000002961394,0.0006826457,0.0000256895,0.006123306,0.0001146085,0.9702601,0.000436991],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6331725,0.003518922,0.003419416,0.006621577,0.001087114,0.006556123,0.02653729,0.0004774244,0.3186096],"genre_scores_gemma":[0.5484358,0.006905622,0.004403061,0.0001597135,0.0009090903,0.000008758308,0.007207309,0.0005944128,0.4313762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3629254,"threshold_uncertainty_score":0.9999251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02710310103691472,"score_gpt":0.3073747619121037,"score_spread":0.280271660875189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}