{"id":"W6981496027","doi":"","title":"Emergence of Nelfinavir and Lopinavir resistance relative to a clinically relevant human immunodeficiency virus type-1 single nucleotide polymorphism at position 36 in protease enzyme «in vitro»","year":2010,"lang":"en","type":"other","venue":"Library and Archives Canada (Government of Canada)","topic":"Historical Studies on Reproduction, Gender, Health, and Societal Changes","field":"Arts and Humanities","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lopinavir; Nelfinavir; Protease; Single-nucleotide polymorphism; Enzyme; Lentivirus; Human immunodeficiency virus (HIV); Virus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004361793,0.0001099606,0.00007313806,0.0005079299,0.0005732155,0.0005241955,0.0002120592,0.000186888,0.008616843],"category_scores_gemma":[0.0007407993,0.00004197466,0.00006821322,0.000442304,0.000623942,0.0001660673,0.0002220638,0.0003866569,0.0006078659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002348467,"about_ca_system_score_gemma":0.001757444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1055769,"about_ca_topic_score_gemma":0.1620511,"domain_scores_codex":[0.999763,0.00005465343,0.00001036881,0.00003580655,0.00008291526,0.00005331996],"domain_scores_gemma":[0.9996794,0.00007805583,0.00006268279,0.00003081571,0.00009048177,0.00005860899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001927442,0.0007435904,0.2447975,0.0003293935,0.0000305729,0.00963281,0.005347628,0.0004917184,0.02351557,0.04699809,0.06569762,0.6004879],"study_design_scores_gemma":[0.00004961603,0.0003629514,0.5949782,0.0001639763,0.000028276,0.01653788,0.002825531,0.0004535405,0.0142252,0.002877146,0.3674622,0.00003548828],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5661741,0.007644895,0.000586848,0.004109021,0.000233205,0.00009335006,0.002946697,0.0000664952,0.4181454],"genre_scores_gemma":[0.8964058,0.003611853,0.0004903108,0.0007503636,0.0000584655,0.00001499814,0.000787736,0.00001831075,0.09786215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1055769,"threshold_uncertainty_score":0.2099247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390692748083466,"score_gpt":0.1972824203976088,"score_spread":0.1833754929167742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}