{"id":"W6983294184","doi":"","title":"Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk","year":2016,"lang":"en","type":"article","venue":"Oxford University Research Archive (ORA) (University of Oxford)","topic":"Astronomical Observations and Instrumentation","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Austrian Science Fund; Ontario Ministry of Economic Development and Innovation; Genome Canada; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Wellcome Trust; Enamine; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; BRD4; Chromatin; Histone; Acetylation; Epigenetics; BET inhibitor; Small molecule; Gene; Lysine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324345,0.000128072,0.0001593661,0.0003108955,0.0001297439,0.0002456536,0.0002178921,0.0002657195,0.002371715],"category_scores_gemma":[0.000119317,0.0001791774,0.0001738802,0.0001680229,0.0002159371,0.0001592897,0.0001870982,0.0002929874,0.0002652761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003277686,"about_ca_system_score_gemma":0.0001116143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004135372,"about_ca_topic_score_gemma":0.0008825954,"domain_scores_codex":[0.9999111,0.00001018264,0.000002808451,0.0000286891,0.00002453913,0.00002259045],"domain_scores_gemma":[0.9999453,0.00001637551,0.00001833355,0.000005579751,0.000005735691,0.000008662221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005820227,0.000008694983,0.000285981,0.00002336063,0.000004116662,0.00001084319,0.000004761786,0.0001456125,0.9974312,0.00007158695,0.00001601657,0.001939568],"study_design_scores_gemma":[0.00001147574,0.0001692319,0.003891441,0.000001827275,0.000007851381,0.00008715932,0.0000116302,0.0008902145,0.9941149,0.00004997584,0.0007614521,0.000002963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883587,0.002279962,0.006227534,0.00009964733,0.000008475331,0.00002540385,0.0002971628,0.00008379463,0.002619162],"genre_scores_gemma":[0.9942057,0.0007344421,0.003349764,0.00004695295,0.000003331977,0.0000160395,0.0002459354,0.00001448827,0.00138332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002371715,"threshold_uncertainty_score":0.007934213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02703595876394913,"score_gpt":0.2360876519418859,"score_spread":0.2090516931779368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}