{"id":"W6983536177","doi":"","title":"Model Based Design of a Saccharomyces cerevisiae Platform Strain with Improved Tyrosine Production Capabilities","year":2012,"lang":"en","type":"dissertation","venue":"TSpace (University of Toronto)","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Saccharomyces cerevisiae; Yeast; Strain (injury); Tyrosine; Metabolic engineering; Shikimate pathway; Production (economics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525112,0.000198018,0.0002799787,0.00003800346,0.00005270086,0.000003837815,0.0001421892,0.0002315851,0.0002199513],"category_scores_gemma":[0.00002080435,0.0002071181,0.00008535758,0.00003842577,0.0000640695,0.00002360618,0.00001426294,0.00007594619,4.399101e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004794953,"about_ca_system_score_gemma":0.0001514339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005391156,"about_ca_topic_score_gemma":0.006417892,"domain_scores_codex":[0.999301,0.00002221894,0.0001084228,0.0002960155,0.0001113948,0.0001610019],"domain_scores_gemma":[0.9991852,0.000002343284,0.0002553109,0.0003108951,0.0002000248,0.00004622923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007268647,0.00007174227,0.00001156926,0.0004827477,0.00009397745,1.149352e-7,0.001259304,0.002822789,0.9883807,0.00001514765,0.0001133869,0.006021643],"study_design_scores_gemma":[0.001370821,0.001147159,0.01194263,0.0004115955,0.0006441276,0.000006579859,0.01268781,0.005938393,0.9644418,0.000006698693,0.0005278583,0.0008745177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981272,0.002758099,0.01419366,0.00005820921,0.0002720397,0.000569505,0.0001061944,0.00002627452,0.0007439496],"genre_scores_gemma":[0.9765791,0.0003306794,0.01624881,0.000001595765,0.0001218677,0.000001182449,0.0005984457,0.00002308298,0.006095234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0239389,"threshold_uncertainty_score":0.8446029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184364570046396,"score_gpt":0.2117620203451682,"score_spread":0.1999183746447042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}