{"id":"W6983607664","doi":"","title":"Mutations in the PAS domain of the HERG potassium channel impacts cell surface expression and stability","year":2004,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Assisted Reproductive Technology and Twin Pregnancy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"hERG; Potassium channel; Domain (mathematical analysis); Mutation; Cell; Channel (broadcasting); PAS domain; Potassium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001244257,0.0005184024,0.0006795354,0.0001880829,0.000715717,0.00001665473,0.0004906273,0.0009587952,0.00004352492],"category_scores_gemma":[0.0009380372,0.0003282994,0.0002573981,0.0007827045,0.0003281008,0.0002455092,0.0001283885,0.002322968,0.00000843413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000378253,"about_ca_system_score_gemma":0.0001618301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001851177,"about_ca_topic_score_gemma":0.0006862885,"domain_scores_codex":[0.9966171,0.0006267659,0.0007535584,0.000913758,0.0006132543,0.0004755711],"domain_scores_gemma":[0.9973202,0.0002633512,0.0006412823,0.001368995,0.000287377,0.0001187737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001119154,0.002700973,0.005207338,0.003474268,0.0002566836,0.000214434,0.0009622526,0.00006647596,0.9648322,0.01536274,0.000007271065,0.005796193],"study_design_scores_gemma":[0.002643902,0.0003092379,0.1184789,0.002707674,0.0003739031,0.0001133334,0.007100576,0.000001785593,0.8140236,0.05327438,0.0004446134,0.0005281506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795399,0.001797654,2.412817e-7,0.0002898596,0.0004610295,0.001652096,0.0003165667,0.00008681462,0.0158559],"genre_scores_gemma":[0.9984259,0.0001768117,0.0003216983,0.0001084525,0.00001963441,0.0000927106,0.0002209451,0.00007238346,0.0005614826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1508087,"threshold_uncertainty_score":0.9999787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718719286860214,"score_gpt":0.2493575212257849,"score_spread":0.2321703283571828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}