{"id":"W6986185860","doi":"","title":"Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and alpha-synuclein mechanisms","year":2019,"lang":"en","type":"article","venue":"Data Archiving and Networked Services (DANS)","topic":"Fetal and Pediatric Neurological Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Neurological Disorders and Stroke; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Bundesministerium für Bildung und Forschung; Parkinson's UK; Multiple System Atrophy Coalition; Canada First Research Excellence Fund; Bristol-Myers Squibb; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; University of Glasgow; EU Joint Programme – Neurodegenerative Disease Research; University College London; Wellcome Trust; Deutsche Forschungsgemeinschaft; McGill University; Helsingin Yliopisto; U.S. Department of Defense; Eli Lilly and Company; Itä-Suomen Yliopisto; Michael J. Fox Foundation for Parkinson's Research; National Institute on Aging; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Pfizer; Biogen; Helsingin ja Uudenmaan Sairaanhoitopiiri; GlaxoSmithKline; U.S. Department of Health and Human Services","keywords":"Disease; Association (psychology); Genetic association; Age of onset; Population; Genome-wide association study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001418617,0.0004760943,0.0006468438,0.001674379,0.0006861567,0.001111753,0.0004430187,0.0006182914,0.001812453],"category_scores_gemma":[0.003074858,0.0003468032,0.0008495795,0.001811182,0.0003216487,0.0005071979,0.0007609269,0.0006638853,0.000227659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002291573,"about_ca_system_score_gemma":0.0003044585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00471217,"about_ca_topic_score_gemma":0.006487498,"domain_scores_codex":[0.998801,0.0004086944,0.0001821353,0.0003780842,0.0001350785,0.0000950248],"domain_scores_gemma":[0.9979509,0.0006696069,0.000696736,0.0003176269,0.0001757721,0.0001892898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005977222,0.00005122152,0.9886861,0.00002524364,0.0004321348,0.0009334384,0.0002906813,0.00009178271,0.003280423,0.0001864385,0.000280894,0.005144],"study_design_scores_gemma":[0.00001507353,0.0000554478,0.997622,0.00001095719,0.0002649372,0.0009255385,0.0001304573,0.0002227376,0.0002940641,0.0001874738,0.0002664415,0.000004920812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958785,0.0009067959,0.001049069,0.0001397066,0.00002068174,0.00001249699,0.001004527,0.00002356302,0.0009647331],"genre_scores_gemma":[0.9979978,0.0003542786,0.0005840656,0.00003601226,0.00001991641,0.00001021496,0.000620766,0.00001327329,0.0003637256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00471217,"threshold_uncertainty_score":0.009369493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199501636218868,"score_gpt":0.2273477478516724,"score_spread":0.2153527314894837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}