{"id":"W6986185860","doi":"","title":"Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and alpha-synuclein mechanisms","year":2019,"lang":"en","type":"article","venue":"Data Archiving and Networked Services (DANS)","topic":"Fetal and Pediatric Neurological Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Neurological Disorders and Stroke; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Bundesministerium für Bildung und Forschung; Parkinson's UK; Multiple System Atrophy Coalition; Canada First Research Excellence Fund; Bristol-Myers Squibb; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; University of Glasgow; EU Joint Programme – Neurodegenerative Disease Research; University College London; Wellcome Trust; Deutsche Forschungsgemeinschaft; McGill University; Helsingin Yliopisto; U.S. Department of Defense; Eli Lilly and Company; Itä-Suomen Yliopisto; Michael J. Fox Foundation for Parkinson's Research; National Institute on Aging; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Pfizer; Biogen; Helsingin ja Uudenmaan Sairaanhoitopiiri; GlaxoSmithKline; U.S. Department of Health and Human Services","keywords":"Disease; Association (psychology); Genetic association; Age of onset; Population; Genome-wide association study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005318594,0.0002634868,0.0004066149,0.00005479887,0.0002342121,0.00007999474,0.0003437136,0.00007132352,0.00006658633],"category_scores_gemma":[0.00007565262,0.0002181256,0.00004864617,0.000164708,0.00004824388,0.0001317318,0.001091368,0.00025558,0.00003977602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003578218,"about_ca_system_score_gemma":0.00002193852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000248857,"about_ca_topic_score_gemma":0.0008022852,"domain_scores_codex":[0.9978076,0.000273378,0.0003108375,0.0008230949,0.0003399173,0.0004451627],"domain_scores_gemma":[0.998098,0.0006851741,0.0001453185,0.0007152591,0.00001799733,0.0003382601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003921812,0.0001821658,0.9960741,0.0002966526,0.00007861733,0.00009956017,0.0008053312,0.00007789196,0.0001082192,0.000005555057,0.000152683,0.001727041],"study_design_scores_gemma":[0.001063699,0.000401944,0.9821582,0.00004219961,0.0002779354,0.000006638427,0.0003782225,0.01024831,6.768404e-7,0.0007674075,0.004426037,0.0002286856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967028,0.001247133,0.00007514923,0.0004760704,0.0001033168,0.0006648189,0.0003483638,0.00009324299,0.0002890461],"genre_scores_gemma":[0.9953306,0.0008627499,0.0004978248,0.001654808,0.0000828078,0.00001945864,0.001306876,0.00003239939,0.0002124659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01391586,"threshold_uncertainty_score":0.8894905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199501636218868,"score_gpt":0.2273477478516724,"score_spread":0.2153527314894837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}