{"id":"W6986957678","doi":"","title":"RNAi as a Potential Targeted Therapy in Oculopharyngeal Muscular Dystrophy","year":2025,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Data Privacy and Cybersecurity","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Oculopharyngeal muscular dystrophy; Targeted therapy; RNA interference; Muscular dystrophy; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002120453,0.0008170747,0.0009860678,0.0007020794,0.002650084,0.0002742051,0.001942609,0.001468815,0.001554303],"category_scores_gemma":[0.001464596,0.0009159594,0.0006329736,0.001517226,0.0001689177,0.001375024,0.0001975572,0.002176219,0.0004144959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008814247,"about_ca_system_score_gemma":0.0004857278,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02501285,"about_ca_topic_score_gemma":0.02830627,"domain_scores_codex":[0.9928843,0.001831963,0.0009991209,0.001461874,0.001593052,0.001229704],"domain_scores_gemma":[0.9974985,0.0001988975,0.0005045104,0.0009426651,0.0004162519,0.000439145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001929608,0.001516179,0.0001097261,0.000431049,0.0008322336,0.001298277,0.0008025004,0.00002543076,0.01609696,0.4872357,0.0001443938,0.4895779],"study_design_scores_gemma":[0.005279849,0.0004401189,0.006429791,0.0009443606,0.0003660454,0.000009746367,0.009374649,0.00001470374,0.01627178,0.1877077,0.7699471,0.00321421],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8080041,0.001047243,8.526293e-8,0.0000763252,0.002714023,0.001111967,0.001401047,0.0002719382,0.1853733],"genre_scores_gemma":[0.9812717,0.003178683,0.0001866146,0.0004910685,0.0001785972,0.0002115707,0.002965135,0.0001047451,0.01141184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7698027,"threshold_uncertainty_score":0.9998275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350936869213929,"score_gpt":0.2758272191456468,"score_spread":0.2623178504535075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}