{"id":"W6987672446","doi":"","title":"Tumor Infiltrating Effector Memory Antigen-Specific CD8<sup>+</sup> T Cells Predict Response to Immune Checkpoint Therapy","year":2020,"lang":"en","type":"article","venue":"UWA Profiles and Research Repository (University of Western Australia)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Centre for Global Health Research","funders":"","keywords":"Immune system; Effector; Immune checkpoint; Nivolumab; Immunotherapy; Tumor-infiltrating lymphocytes; Cytotoxic T cell; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957983,0.0002042606,0.0002522144,0.000274881,0.000120619,0.0004854651,0.0001513206,0.0003537853,0.003163777],"category_scores_gemma":[0.000914801,0.0001198197,0.0001109592,0.0001584114,0.0001461512,0.0003325815,0.0001454234,0.0005112832,0.0009395208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586092,"about_ca_system_score_gemma":0.0001037366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003145324,"about_ca_topic_score_gemma":0.0005172424,"domain_scores_codex":[0.9998903,0.00002161841,0.000009478825,0.00002846666,0.00001844306,0.00003153858],"domain_scores_gemma":[0.9995962,0.0001059544,0.0001067528,0.00004320664,0.00004854177,0.00009937921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006886535,0.0007321064,0.8602602,0.00006224358,0.00006790468,0.0002433419,0.00009640347,0.001463186,0.05664885,0.0002044514,0.002579102,0.07075576],"study_design_scores_gemma":[0.0002081382,0.004433472,0.9552958,0.00003552359,0.0001459118,0.002183444,0.0002563677,0.007392401,0.02366915,0.0006326406,0.005728504,0.00001860181],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973845,0.000187437,0.000203896,0.00004902506,0.00001851155,0.00001574728,0.0002130334,0.0000216709,0.001906123],"genre_scores_gemma":[0.9982287,0.00004623716,0.0001827355,0.00005852689,0.0000170373,0.00001683255,0.0002774825,0.000007423204,0.001165063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003163777,"threshold_uncertainty_score":0.01058394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05976505121425801,"score_gpt":0.2990086156476747,"score_spread":0.2392435644334167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}