{"id":"W6989866012","doi":"","title":"Chiral Analysis of d- and l-Ritalinic Acids in Biological Samples and the Stereoselective Metabolism of d- and l-Methylphenidate","year":2023,"lang":"en","type":"dissertation","venue":"University Library (University of Saskatchewan)","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Enantiomer; Pharmacokinetics; In vivo; Enantioselective synthesis; In vitro; Stereoselectivity; Metabolism; Hydrolysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004325735,0.0003957093,0.000286578,0.0003422368,0.0001994857,0.0003406343,0.0001371957,0.0003659926,0.0004896827],"category_scores_gemma":[0.0007251118,0.0001647602,0.000217012,0.0002106859,0.0003203939,0.0002626677,0.0001869044,0.0003538088,0.0002753274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799599,"about_ca_system_score_gemma":0.0004647654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287136,"about_ca_topic_score_gemma":0.001546325,"domain_scores_codex":[0.9996365,0.0001374577,0.00002630035,0.00006207641,0.0001030672,0.0000345014],"domain_scores_gemma":[0.9997781,0.00005777646,0.00005674083,0.00002579241,0.00005895489,0.00002258971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568236,0.0000166833,0.0007623911,0.00005081485,0.0000132941,0.00008741019,0.0000294888,0.00005971536,0.9941545,0.00007968882,0.00001144797,0.004577831],"study_design_scores_gemma":[0.00001229027,0.0002114631,0.002936969,0.000005788634,0.00001909957,0.0004326091,0.00004412364,0.0008749125,0.9945124,0.00005265042,0.0008863953,0.00001116339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503621,0.004954712,0.04103724,0.0001649614,0.00004322371,0.0001456812,0.0004274136,0.00008610191,0.002778458],"genre_scores_gemma":[0.948769,0.00474787,0.04296706,0.000228046,0.00003027353,0.0001348624,0.000529573,0.00003426429,0.002558997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287136,"threshold_uncertainty_score":0.002559364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009767744274320499,"score_gpt":0.2022484115502562,"score_spread":0.1924806672759357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}