{"id":"W6989879863","doi":"","title":"CHARACTERIZATION OF BINDING AND ACTIVATION MECHANISMS OF BAK","year":2025,"lang":"en","type":"dissertation","venue":"MacSphere (McMaster University)","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Programmed cell death; Apoptosis; Transfection; Multicellular organism; Confocal microscopy; Förster resonance energy transfer; Cell culture; Confocal; Mitochondrion; Plasma protein binding","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510865,0.0004211134,0.0002773452,0.0004644998,0.0004324831,0.0003346871,0.0005642166,0.0005068439,0.006529982],"category_scores_gemma":[0.0006114659,0.0001603384,0.0003648246,0.0004051022,0.0001916656,0.0005033557,0.0002332532,0.0008720247,0.002079556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000422464,"about_ca_system_score_gemma":0.0002014704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006842986,"about_ca_topic_score_gemma":0.000584627,"domain_scores_codex":[0.9996949,0.00002499153,0.00001786105,0.00009814964,0.00007775079,0.00008639072],"domain_scores_gemma":[0.9995912,0.0001266577,0.00006768797,0.00004414061,0.00009072833,0.00007971076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224974,0.00001727628,0.0002219415,0.00007101576,0.000005204414,0.0000259813,0.00002213871,0.0001283048,0.9980838,0.0002005258,0.00006790843,0.001033333],"study_design_scores_gemma":[0.000009534489,0.000103021,0.004205773,0.000008566293,0.0000136601,0.0003943322,0.00003960882,0.002008118,0.9882023,0.0002252904,0.004776875,0.00001289827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613711,0.004439009,0.02661886,0.0002327797,0.00005623769,0.00008011723,0.003280322,0.0001906832,0.003730997],"genre_scores_gemma":[0.9777013,0.001026816,0.008543248,0.0001091512,0.00001540558,0.00009192039,0.006429547,0.00009253457,0.005990022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006529982,"threshold_uncertainty_score":0.02184498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006504705054413308,"score_gpt":0.190265025539555,"score_spread":0.1837603204851417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}