{"id":"W6990412572","doi":"","title":"Design, synthesis, and evaluation of vitamin D receptor agonist/histone deacetylase inhibitor hybrids for improved pharmacokinetic profiles","year":2019,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Pharmacokinetics; Histone deacetylase inhibitor; Receptor; Calcitriol receptor; Vitamin D and neurology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654782,0.0002943767,0.0002742337,0.0001483522,0.0001483413,0.0003981224,0.0002822148,0.0002819375,0.002785372],"category_scores_gemma":[0.000167041,0.0001680072,0.0003455477,0.000179713,0.0000950358,0.0002858865,0.0002012608,0.0004735639,0.001077209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260484,"about_ca_system_score_gemma":0.0002021597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003676057,"about_ca_topic_score_gemma":0.0008065142,"domain_scores_codex":[0.9999256,0.000009202168,0.000004927352,0.00002090914,0.00001731192,0.00002206111],"domain_scores_gemma":[0.9999467,0.0000101789,0.00001520205,0.000004276918,0.00001251642,0.00001107403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003844046,0.0001552611,0.0001378855,0.0002106675,0.00004712256,0.0001077654,0.00005959259,0.001736339,0.9664001,0.0009952589,0.0007439259,0.02902159],"study_design_scores_gemma":[0.0001680739,0.002064513,0.0005775472,0.00002020726,0.00008540727,0.0001554429,0.00004357042,0.001859736,0.9683785,0.0001841768,0.02643695,0.00002587039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956333,0.01487593,0.06346625,0.0006353155,0.0003763461,0.0007402858,0.001837575,0.0006271406,0.02180791],"genre_scores_gemma":[0.9469476,0.005982908,0.0301664,0.0003546942,0.00004001964,0.0003197633,0.0009570184,0.00009727031,0.01513437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002785372,"threshold_uncertainty_score":0.009318054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03671720124887361,"score_gpt":0.3325987988161168,"score_spread":0.2958815975672431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}